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    FCN1 ficolin 1 [ Homo sapiens (human) ]

    Gene ID: 2219, updated on 9-Dec-2024

    Summary

    Official Symbol
    FCN1provided by HGNC
    Official Full Name
    ficolin 1provided by HGNC
    Primary source
    HGNC:HGNC:3623
    See related
    Ensembl:ENSG00000085265 MIM:601252; AllianceGenome:HGNC:3623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCNM
    Summary
    The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 318.5), appendix (RPKM 117.5) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FCN1 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (134903232..134917912, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (147124901..147139590, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (137795078..137809758, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101448202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29288 Neighboring gene microRNA 3689f Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137755823-137756551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137756552-137757279 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:137764334-137764507 Neighboring gene MPRA-validated peak7344 silencer Neighboring gene ficolin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137781651-137782151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137820358-137821216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137821217-137822074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29291 Neighboring gene uncharacterized LOC105376314 Neighboring gene uncharacterized LOC124902302 Neighboring gene uncharacterized LOC105376313

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 significantly inhibits FCN1 expression in human PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate derivative binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pattern recognition receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sialic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    part_of serine-type endopeptidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ficolin-1
    Names
    M-ficolin
    ficolin (collagen/fibrinogen domain-containing) 1
    ficolin-A
    ficolin-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046982.2 RefSeqGene

      Range
      5049..19729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002003.5 → NP_001994.2  ficolin-1 precursor

      See identical proteins and their annotated locations for NP_001994.2

      Status: REVIEWED

      Source sequence(s)
      AK314867, AL353611, AL603650, AL833097, BC020635, DA813504
      Consensus CDS
      CCDS6985.1
      UniProtKB/Swiss-Prot
      O00602, Q5VYV5, Q92596
      Related
      ENSP00000360871.3, ENST00000371806.4
      Conserved Domains (2) summary
      pfam01391
      Location:51 → 107
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:115 → 325
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      134903232..134917912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      147124901..147139590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)