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    PXYLP1 2-phosphoxylose phosphatase 1 [ Homo sapiens (human) ]

    Gene ID: 92370, updated on 27-Nov-2024

    Summary

    Official Symbol
    PXYLP1provided by HGNC
    Official Full Name
    2-phosphoxylose phosphatase 1provided by HGNC
    Primary source
    HGNC:HGNC:26303
    See related
    Ensembl:ENSG00000155893 MIM:619732; AllianceGenome:HGNC:26303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XYLP; ACPL2; HEL124
    Summary
    Enables phosphatase activity. Involved in chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of heparan sulfate proteoglycan biosynthetic process. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 6.1), placenta (RPKM 4.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PXYLP1 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (141231825..141294924)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (143979382..144042517)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (140950667..141013766)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:140661115-140661962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20620 Neighboring gene solute carrier family 25 member 36 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14772 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:140789226-140789769 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:140789770-140790312 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:140792837-140793422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:140802197-140802706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:140805486-140806259 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 4 Neighboring gene NANOG hESC enhancer GRCh37_chr3:140821789-140822305 Neighboring gene NANOG hESC enhancer GRCh37_chr3:140923620-140924130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:140925635-140926136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:140978638-140979382 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64847 Neighboring gene ribosomal protein L31 pseudogene 21 Neighboring gene uncharacterized LOC124909441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20623 Neighboring gene PHF5A pseudogene 7 Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:141086748-141087947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20625 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:141092856-141093449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20630 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:141111788-141112397 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:141112398-141113008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20631 Neighboring gene uncharacterized LOC124906291

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23751

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    2-phosphoxylose phosphatase 1
    Names
    acid phosphatase-like 2
    acid phosphatase-like protein 2
    epididymis luminal protein 124
    xylosyl phosphatase
    NP_001032249.1
    NP_001269657.1
    NP_689495.1
    XP_005247960.1
    XP_024309598.1
    XP_047305165.1
    XP_047305166.1
    XP_047305167.1
    XP_047305168.1
    XP_047305169.1
    XP_047305170.1
    XP_047305171.1
    XP_047305172.1
    XP_047305173.1
    XP_047305174.1
    XP_047305175.1
    XP_047305176.1
    XP_047305177.1
    XP_047305178.1
    XP_047305179.1
    XP_047305180.1
    XP_047305181.1
    XP_047305182.1
    XP_047305183.1
    XP_047305184.1
    XP_047305185.1
    XP_047305186.1
    XP_047305187.1
    XP_054204390.1
    XP_054204391.1
    XP_054204392.1
    XP_054204393.1
    XP_054204394.1
    XP_054204395.1
    XP_054204396.1
    XP_054204397.1
    XP_054204398.1
    XP_054204399.1
    XP_054204400.1
    XP_054204401.1
    XP_054204402.1
    XP_054204403.1
    XP_054204404.1
    XP_054204405.1
    XP_054204406.1
    XP_054204407.1
    XP_054204408.1
    XP_054204409.1
    XP_054204410.1
    XP_054204411.1
    XP_054204412.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037172.3NP_001032249.1  2-phosphoxylose phosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_001032249.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC117383, AK074331, AL137529, BX647621, CX762355, DC409719
      Consensus CDS
      CCDS3116.1
      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
      Related
      ENSP00000286353.4, ENST00000286353.9
      Conserved Domains (1) summary
      cl11399
      Location:87424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    2. NM_001282728.2NP_001269657.1  2-phosphoxylose phosphatase 1 isoform 2

      See identical proteins and their annotated locations for NP_001269657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC117383, AK074331, AK297790, AL137529, BX647621, CX762355
      Consensus CDS
      CCDS63797.1
      UniProtKB/TrEMBL
      B7Z4T2
      Related
      ENSP00000422558.1, ENST00000502783.5
      Conserved Domains (1) summary
      cl11399
      Location:49386
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    3. NM_152282.5NP_689495.1  2-phosphoxylose phosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_689495.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC117383, AK074331, AK316121, AL137529, AY358460, BX647621, CX762355
      Consensus CDS
      CCDS3116.1
      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
      Related
      ENSP00000376733.2, ENST00000393010.6
      Conserved Domains (1) summary
      cl11399
      Location:87424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      141231825..141294924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449228.1XP_047305184.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    2. XM_047449230.1XP_047305186.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    3. XM_047449223.1XP_047305179.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    4. XM_047449229.1XP_047305185.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    5. XM_047449209.1XP_047305165.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    6. XM_047449214.1XP_047305170.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    7. XM_047449220.1XP_047305176.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    8. XM_047449219.1XP_047305175.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    9. XM_047449210.1XP_047305166.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    10. XM_047449215.1XP_047305171.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    11. XM_047449224.1XP_047305180.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    12. XM_047449216.1XP_047305172.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    13. XM_047449212.1XP_047305168.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    14. XM_047449225.1XP_047305181.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    15. XM_047449211.1XP_047305167.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    16. XM_047449222.1XP_047305178.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    17. XM_047449221.1XP_047305177.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    18. XM_047449226.1XP_047305182.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    19. XM_047449218.1XP_047305174.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    20. XM_047449227.1XP_047305183.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    21. XM_047449213.1XP_047305169.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    22. XM_047449217.1XP_047305173.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    23. XM_024453830.2XP_024309598.1  2-phosphoxylose phosphatase 1 isoform X2

      UniProtKB/TrEMBL
      E9PDB7
      Related
      ENSP00000422901.1, ENST00000508812.1
      Conserved Domains (1) summary
      cl11399
      Location:78415
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    24. XM_047449231.1XP_047305187.1  2-phosphoxylose phosphatase 1 isoform X4

      UniProtKB/TrEMBL
      B7Z4T2
    25. XM_005247903.5XP_005247960.1  2-phosphoxylose phosphatase 1 isoform X3

      See identical proteins and their annotated locations for XP_005247960.1

      UniProtKB/TrEMBL
      B7Z3R9
      Related
      ENSP00000426877.1, ENST00000504264.5
      Conserved Domains (1) summary
      cl11399
      Location:70407
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      143979382..144042517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348416.1XP_054204391.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    2. XM_054348415.1XP_054204390.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    3. XM_054348417.1XP_054204392.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    4. XM_054348422.1XP_054204397.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    5. XM_054348428.1XP_054204403.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    6. XM_054348423.1XP_054204398.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    7. XM_054348419.1XP_054204394.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    8. XM_054348429.1XP_054204404.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    9. XM_054348418.1XP_054204393.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    10. XM_054348427.1XP_054204402.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    11. XM_054348426.1XP_054204401.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    12. XM_054348430.1XP_054204405.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    13. XM_054348425.1XP_054204400.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    14. XM_054348421.1XP_054204396.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    15. XM_054348432.1XP_054204407.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    16. XM_054348431.1XP_054204406.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    17. XM_054348420.1XP_054204395.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    18. XM_054348434.1XP_054204409.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    19. XM_054348433.1XP_054204408.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    20. XM_054348424.1XP_054204399.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNF5, Q49AJ2, Q8TE99, W0TR04
    21. XM_054348436.1XP_054204411.1  2-phosphoxylose phosphatase 1 isoform X3

      UniProtKB/TrEMBL
      B7Z3R9
    22. XM_054348435.1XP_054204410.1  2-phosphoxylose phosphatase 1 isoform X2

      UniProtKB/TrEMBL
      E9PDB7
    23. XM_054348437.1XP_054204412.1  2-phosphoxylose phosphatase 1 isoform X4

      UniProtKB/TrEMBL
      B7Z4T2