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    NLRP10 NLR family pyrin domain containing 10 [ Homo sapiens (human) ]

    Gene ID: 338322, updated on 27-Nov-2024

    Summary

    Official Symbol
    NLRP10provided by HGNC
    Official Full Name
    NLR family pyrin domain containing 10provided by HGNC
    Primary source
    HGNC:HGNC:21464
    See related
    Ensembl:ENSG00000182261 MIM:609662; AllianceGenome:HGNC:21464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOD8; PAN5; PYNOD; NALP10; CLR11.1
    Summary
    Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward skin (RPKM 2.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NLRP10 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (7957537..7965447, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8036705..8044619, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (7979084..7986994, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily A member 6 (gene/pseudogene) Neighboring gene olfactory receptor family 10 subfamily A member 3 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:8008582-8009121 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:8009122-8009660 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:8016231-8017430 Neighboring gene eukaryotic translation initiation factor 3 subunit F

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    NACHT, LRR and PYD domains-containing protein 10
    Names
    NACHT, leucine rich repeat and PYD containing 10
    nucleotide-binding oligomerization domain protein 8
    nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046899.1 RefSeqGene

      Range
      4978..12888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001391958.1NP_001378887.1  NACHT, LRR and PYD domains-containing protein 10

      Status: REVIEWED

      Source sequence(s)
      AC044810
      Consensus CDS
      CCDS7784.1
      UniProtKB/Swiss-Prot
      Q2M3C4, Q6JGT0, Q86W26
      Related
      ENSP00000509542.1, ENST00000691676.1
      Conserved Domains (3) summary
      cd08321
      Location:1090
      Pyrin_ASC-like; Pyrin Death Domain found in ASC
      pfam05729
      Location:167331
      NACHT; NACHT domain
      pfam17779
      Location:409464
      NOD2_WH; NOD2 winged helix domain
    2. NM_176821.4NP_789791.1  NACHT, LRR and PYD domains-containing protein 10

      See identical proteins and their annotated locations for NP_789791.1

      Status: REVIEWED

      Source sequence(s)
      AC044810, AY489192
      Consensus CDS
      CCDS7784.1
      UniProtKB/Swiss-Prot
      Q2M3C4, Q6JGT0, Q86W26
      Related
      ENSP00000327763.2, ENST00000328600.3
      Conserved Domains (3) summary
      cd08321
      Location:1090
      Pyrin_ASC-like; Pyrin Death Domain found in ASC
      pfam05729
      Location:167331
      NACHT; NACHT domain
      pfam17779
      Location:409464
      NOD2_WH; NOD2 winged helix domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      7957537..7965447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332695.1 Reference GRCh38.p14 PATCHES

      Range
      188531..196441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187583.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      189038..196948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      8036705..8044619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)