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    IFITM10 interferon induced transmembrane protein 10 [ Homo sapiens (human) ]

    Gene ID: 402778, updated on 27-Nov-2024

    Summary

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    Official Symbol
    IFITM10provided by HGNC
    Official Full Name
    interferon induced transmembrane protein 10provided by HGNC
    Primary source
    HGNC:HGNC:40022
    See related
    Ensembl:ENSG00000244242 MIM:618293; AllianceGenome:HGNC:40022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSPA3
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal (RPKM 13.9), brain (RPKM 6.2) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IFITM10 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1732406..1750595, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1817953..1836145, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1753636..1771825, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2708 Neighboring gene keratin associated protein 5-6 Neighboring gene skeletal muscle cis-regulatory module in IFITM10 intron Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1770125-1770880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1770881-1771636 Neighboring gene cathepsin D Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3058 Neighboring gene PRC2 and DDX5 associated lncRNA Neighboring gene uncharacterized LOC105376517

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The dispanins: a novel gene family of ancient origin that contains 14 human members. Sällman Almén M, et al. PLoS One, 2012. PMID 22363774, Free PMC Article
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CTSD

    Homology

    Clone Names

    • FLJ12231, FLJ76511

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced transmembrane protein 10
    Names
    dispanin subfamily A member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170820.4 → NP_001164291.2  interferon-induced transmembrane protein 10

      See identical proteins and their annotated locations for NP_001164291.2

      Status: VALIDATED

      Source sequence(s)
      AC068580, BQ183689, BQ669640, DB219779
      Consensus CDS
      CCDS53593.2
      UniProtKB/Swiss-Prot
      A6NEU7, A6NMD0
      Related
      ENSP00000344430.4, ENST00000340134.5
      Conserved Domains (1) summary
      pfam04505
      Location:145 → 216
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      1732406..1750595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187657.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      206152..209195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      1817953..1836145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NMD0.1 GenPept UniProtKB/Swiss-Prot:A6NMD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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