Idh3a isocitrate dehydrogenase 3 (NAD+) alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Idh3aprovided by MGI
Official Full Name: isocitrate dehydrogenase 3 (NAD+) alphaprovided by MGI
Primary source: MGI:MGI:1915084
See related: Ensembl:ENSMUSG00000032279 AllianceGenome:MGI:1915084
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110003P10Rik; 1500012E04Rik
Summary: Predicted to enable isocitrate dehydrogenase (NAD+) activity and magnesium ion binding activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 153.2), cerebellum adult (RPKM 51.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.7 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (54493795..54511946)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (54586511..54604662)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-9-5p regulates immunometabolic and epigenetic pathways in beta-glucan-trained immunity via IDH3alpha.
Title: miR-9-5p regulates immunometabolic and epigenetic pathways in β-glucan-trained immunity via IDH3α.
the role of IDH3 in retinal disease and mitochondrial function, was investigated.
Title: Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124560 (e-PCR)
- UniSTS:161382

RH125646 (e-PCR)
- UniSTS:162434

AI316514 (e-PCR)
- UniSTS:159880

RH125183 (e-PCR)
- UniSTS:162005

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables isocitrate dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of isocitrate dehydrogenase complex (NAD+)	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	NAS Non-traceable Author Statement more info	PubMed
located_in myelin sheath	HDA more info	PubMed

General protein information

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Preferred Names: isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Names: NAD(+)-specific ICDH subunit alpha; isocitric dehydrogenase subunit alpha

NP_083849.1

EC 1.1.1.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029573.2 → NP_083849.1 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor

See identical proteins and their annotated locations for NP_083849.1

Status: PROVISIONAL

Source sequence(s)

BC049956

Consensus CDS

CCDS23191.1

UniProtKB/Swiss-Prot

Q3UAM8, Q8C8A1, Q9D1L1, Q9D6R2

Related

ENSMUSP00000127526.2, ENSMUST00000167866.2

Conserved Domains (1) summary

TIGR00175
Location:29 → 362

mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type