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    TRPC3 transient receptor potential cation channel subfamily C member 3 [ Homo sapiens (human) ]

    Gene ID: 7222, updated on 3-Dec-2024

    Summary

    Official Symbol
    TRPC3provided by HGNC
    Official Full Name
    transient receptor potential cation channel subfamily C member 3provided by HGNC
    Primary source
    HGNC:HGNC:12335
    See related
    Ensembl:ENSG00000138741 MIM:602345; AllianceGenome:HGNC:12335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRP3; SCA41
    Summary
    The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRPC3 in Genome Data Viewer
    Location:
    4q27
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (121874481..121952060, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (125178529..125256098, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122795636..122873215, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21872 Neighboring gene BBS7 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15661 Neighboring gene uncharacterized LOC102724158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21873 Neighboring gene Sharpr-MPRA regulatory region 11420 Neighboring gene uncharacterized LOC112268469 Neighboring gene RNA, 7SL, cytoplasmic 335, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel activity TAS
    Traceable Author Statement
    more info
     
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol 1,4,5 trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables store-operated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    short transient receptor potential channel 3
    Names
    hTrp-3
    transient receptor protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030368.2 RefSeqGene

      Range
      5000..82579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130698.2NP_001124170.1  short transient receptor potential channel 3 isoform a

      See identical proteins and their annotated locations for NP_001124170.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC079341, AC108930, AY865574, Y13758
      Consensus CDS
      CCDS47130.1
      UniProtKB/Swiss-Prot
      A7VJS1, E9PCJ9, O00593, Q13507, Q15660, Q52M35, Q5G1L5
      UniProtKB/TrEMBL
      J3QTB0
      Related
      ENSP00000368966.3, ENST00000379645.8
      Conserved Domains (4) summary
      cd00204
      Location:119253
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:96890
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:267326
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:146177
      ANK; ANK repeat [structural motif]
    2. NM_001366479.2NP_001353408.1  short transient receptor potential channel 3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC079341, AC108930
      UniProtKB/TrEMBL
      J3QTB0
      Conserved Domains (2) summary
      TIGR00870
      Location:96862
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:146177
      ANK; ANK repeat [structural motif]
    3. NM_003305.2NP_003296.1  short transient receptor potential channel 3 isoform b

      See identical proteins and their annotated locations for NP_003296.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an upstream exon , compared to variant 1, resulting in a different 5' UTR and 5' coding region and translation initiation from an inframe, downstream ATG. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AY865574, Y13758
      Consensus CDS
      CCDS3725.1
      UniProtKB/TrEMBL
      J3QTB0
      Related
      ENSP00000264811.5, ENST00000264811.9
      Conserved Domains (2) summary
      TIGR00870
      Location:23817
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:73104
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      121874481..121952060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532218.4XP_011530520.1  short transient receptor potential channel 3 isoform X3

      UniProtKB/TrEMBL
      J3QTB0
      Conserved Domains (4) summary
      cd00204
      Location:119253
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:96889
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:267326
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:146177
      ANK; ANK repeat [structural motif]
    2. XM_017008578.3XP_016864067.1  short transient receptor potential channel 3 isoform X2

      UniProtKB/TrEMBL
      J3QTB0
    3. XM_011532217.4XP_011530519.1  short transient receptor potential channel 3 isoform X1

      UniProtKB/TrEMBL
      J3QTB0
      Conserved Domains (4) summary
      cd00204
      Location:119253
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:96906
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:267326
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:146177
      ANK; ANK repeat [structural motif]
    4. XM_047416117.1XP_047272073.1  short transient receptor potential channel 3 isoform X5

      UniProtKB/TrEMBL
      J3QTB0
    5. XM_047416116.1XP_047272072.1  short transient receptor potential channel 3 isoform X4

      UniProtKB/TrEMBL
      J3QTB0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      125178529..125256098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350770.1XP_054206745.1  short transient receptor potential channel 3 isoform X3

      UniProtKB/TrEMBL
      J3QTB0
    2. XM_054350769.1XP_054206744.1  short transient receptor potential channel 3 isoform X2

      UniProtKB/TrEMBL
      J3QTB0
    3. XM_054350768.1XP_054206743.1  short transient receptor potential channel 3 isoform X1

      UniProtKB/TrEMBL
      J3QTB0
    4. XM_054350772.1XP_054206747.1  short transient receptor potential channel 3 isoform X5

      UniProtKB/TrEMBL
      J3QTB0
    5. XM_054350771.1XP_054206746.1  short transient receptor potential channel 3 isoform X4

      UniProtKB/TrEMBL
      J3QTB0