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    C22orf15 chromosome 22 open reading frame 15 [ Homo sapiens (human) ]

    Gene ID: 150248, updated on 3-Dec-2024

    Summary

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    Official Symbol
    C22orf15provided by HGNC
    Official Full Name
    chromosome 22 open reading frame 15provided by HGNC
    Primary source
    HGNC:HGNC:15558
    See related
    Ensembl:ENSG00000169314 AllianceGenome:HGNC:15558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N27C7-3
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See C22orf15 in Genome Data Viewer
    Location:
    22q11.23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23762990..23765863)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24210184..24213057)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24105177..24108050)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 70 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24087516-24088016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24088017-24088517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24093057-24093732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24095085-24095758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24096535-24097035 Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24107697-24108496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24108497-24109296 Neighboring gene uncharacterized LOC107985577 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene matrix metallopeptidase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24122834-24123832

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802, Free PMC Article
    2. The DNA sequence of human chromosome 22. Dunham I, et al. Nature, 1999 Dec 2. PMID 10591208
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36561

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein C22orf15
    Names
    protein N27C7-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331041.2 → NP_001317970.1  uncharacterized protein C22orf15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP000348, AP000349
      Consensus CDS
      CCDS82698.1
      UniProtKB/TrEMBL
      A0A0G2JR10, F8W7S3
      Related
      ENSP00000305096.5, ENST00000305199.9

    2. NM_001376903.1 → NP_001363832.1  uncharacterized protein C22orf15 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP000348, AP000349
      Consensus CDS
      CCDS93130.1
      UniProtKB/TrEMBL
      A0A0G2JR07
      Related
      ENSP00000372271.3, ENST00000382821.3
      Conserved Domains (1) summary
      pfam15874
      Location:7 → 106
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    3. NM_001376904.1 → NP_001363833.1  uncharacterized protein C22orf15 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AP000348, AP000349
      Conserved Domains (1) summary
      pfam15874
      Location:7 → 106
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    4. NM_001376905.1 → NP_001363834.1  uncharacterized protein C22orf15 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AP000348, AP000349
      Conserved Domains (1) summary
      pfam15874
      Location:7 → 83
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    5. NM_182520.3 → NP_872326.2  uncharacterized protein C22orf15 isoform 1

      See identical proteins and their annotated locations for NP_872326.2

      Status: VALIDATED

      Source sequence(s)
      AP000348, AP000349
      Consensus CDS
      CCDS13814.2
      UniProtKB/Swiss-Prot
      Q6ICJ7, Q8WYQ4
      UniProtKB/TrEMBL
      A0A0G2JR24
      Related
      ENSP00000384965.4, ENST00000402217.8
      Conserved Domains (1) summary
      pfam15874
      Location:2 → 101
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      23762990..23765863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452160.2 → XP_024307928.1  uncharacterized protein C22orf15 isoform X1

      Conserved Domains (1) summary
      pfam15874
      Location:2 → 90
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    2. XM_047441152.1 → XP_047297108.1  uncharacterized protein C22orf15 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JR24

    3. XM_011529908.3 → XP_011528210.2  uncharacterized protein C22orf15 isoform X3

    4. XM_047441153.1 → XP_047297109.1  uncharacterized protein C22orf15 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JR07

    5. XM_024452161.2 → XP_024307929.1  uncharacterized protein C22orf15 isoform X2

      Conserved Domains (1) summary
      pfam15874
      Location:2 → 83
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    6. XM_017028612.2 → XP_016884101.1  uncharacterized protein C22orf15 isoform X4

    7. XM_017028618.2 → XP_016884107.1  uncharacterized protein C22orf15 isoform X6

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      622..2225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      24210184..24213057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325122.1 → XP_054181097.1  uncharacterized protein C22orf15 isoform X1

    2. XM_054325126.1 → XP_054181101.1  uncharacterized protein C22orf15 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JR24

    3. XM_054325124.1 → XP_054181099.1  uncharacterized protein C22orf15 isoform X3

    4. XM_054325128.1 → XP_054181103.1  uncharacterized protein C22orf15 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JR07

    5. XM_054325123.1 → XP_054181098.1  uncharacterized protein C22orf15 isoform X2

    6. XM_054325125.1 → XP_054181100.1  uncharacterized protein C22orf15 isoform X4

    7. XM_054325127.1 → XP_054181102.1  uncharacterized protein C22orf15 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WYQ4.1 GenPept UniProtKB/Swiss-Prot:Q8WYQ4

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