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    PGLYRP1 peptidoglycan recognition protein 1 [ Homo sapiens (human) ]

    Gene ID: 8993, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PGLYRP1provided by HGNC
    Official Full Name
    peptidoglycan recognition protein 1provided by HGNC
    Primary source
    HGNC:HGNC:8904
    See related
    Ensembl:ENSG00000008438 MIM:604963; AllianceGenome:HGNC:8904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
    Summary
    Enables several functions, including Hsp70 protein binding activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and detection of bacterium. Located in extracellular exosome. Is active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward bone marrow (RPKM 135.5) See more
    Orthologs
    mouse all
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    Genomic context

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    See PGLYRP1 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46019153..46023053, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48846608..48850508, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46522411..46526311, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14833 Neighboring gene Sharpr-MPRA regulatory region 4903 Neighboring gene coiled-coil domain containing 61 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46506355-46506854 Neighboring gene Sharpr-MPRA regulatory region 13926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46524919-46525804 Neighboring gene microRNA 769 Neighboring gene uncharacterized LOC105372421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46535831-46536434 Neighboring gene IGF like family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity. Cho JH, et al. Blood, 2005 Oct 1. PMID 15956276, Free PMC Article
    2. Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells. Sharapova TN, et al. J Innate Immun, 2017. PMID 28977785
    3. The Tag7-Hsp70 cytotoxic complex induces tumor cell necroptosis via permeabilisation of lysosomes and mitochondria. Yashin DV, et al. Biochimie, 2016 Apr. PMID 26796882
    4. Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity. Sharapova TN, et al. J Immunol Res, 2018. PMID 29850628, Free PMC Article
    5. Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis. Luo Q, et al. Mol Med Rep, 2019 Jan. PMID 30431075

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes.
      Title: The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes.
    2. Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1beta levels during menopause.
      Title: Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1β levels during menopause.
    3. Association of peptidoglycan recognition protein 1 to post-myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study.
      Title: Association of peptidoglycan recognition protein 1 to post-myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study.
    4. N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor.
      Title: N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor.
    5. TNF upregulates peptidoglycan recognition protein 1 in esophageal cancer cells to clear the path to its signaling: Making the ""enemy"" a friend.
      Title: TNF upregulates peptidoglycan recognition protein 1 in esophageal cancer cells to clear the path to its signaling: Making the "enemy" a friend.
    6. Circulating PGLYRP1 Levels as a Potential Biomarker for Coronary Artery Disease and Heart Failure.
      Title: Circulating PGLYRP1 Levels as a Potential Biomarker for Coronary Artery Disease and Heart Failure.
    7. Cytokines TNFalpha, IFNgamma and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes.
      Title: Cytokines TNFα, IFNγ and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes.
    8. Inhibition of Chlamydial Infection by CRISPR/Cas9-SAM Mediated Enhancement of Human Peptidoglycan Recognition Proteins Gene Expression in HeLa Cells.
      Title: Inhibition of Chlamydial Infection by CRISPR/Cas9-SAM Mediated Enhancement of Human Peptidoglycan Recognition Proteins Gene Expression in HeLa Cells.
    9. A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.
      Title: A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.
    10. Regulation of Salivary Peptidoglycan Recognition Protein 1 in Adolescents.
      Title: Regulation of Salivary Peptidoglycan Recognition Protein 1 in Adolescents.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126894, MGC126896

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylmuramoyl-L-alanine amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan immune receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan immune receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biological process involved in interaction with host IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in killing of cells of another organism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of natural killer cell differentiation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    peptidoglycan recognition protein 1
    Names
    TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005091.3 → NP_005082.1  peptidoglycan recognition protein 1 precursor

      See identical proteins and their annotated locations for NP_005082.1

      Status: VALIDATED

      Source sequence(s)
      AF242517, DN998360
      Consensus CDS
      CCDS12680.1
      UniProtKB/Swiss-Prot
      O75594, Q4VB36
      Related
      ENSP00000008938.3, ENST00000008938.5
      Conserved Domains (1) summary
      smart00701
      Location:31 → 173
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46019153..46023053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48846608..48850508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75594.1 GenPept UniProtKB/Swiss-Prot:O75594

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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