Plpp1 phospholipid phosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plpp1provided by MGI
Official Full Name: phospholipid phosphatase 1provided by MGI
Primary source: MGI:MGI:108412
See related: Ensembl:ENSMUSG00000021759 AllianceGenome:MGI:108412
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LPP1; mPAP; Hic53; LPP-1; PAP2a; Hpic53; PAP-2a; Ppap2a; PAP2-alpha
Summary: Enables diacylglycerol diphosphate phosphatase activity and lipid phosphatase activity. Involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and sphingolipid metabolic process. Located in caveola. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human PLPP1 (phospholipid phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 77.1), lung adult (RPKM 58.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.93 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (112937311..113004428)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (112800777..112867894)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data identify a novel role for phospholipid phosphate phosphatase type 1 activity and hepatocyte lysophosphatidic acid levels in glucagon sensitivity via a mechanism involving STAT3.
Title: Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3.
Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1.
Title: Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1.
increasing the LPP1 activity in three lines of aggressive cancer cells decreases their abilities to produce tumors and metastases
Title: Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.
Authors demonstrated for the first time that lipin-1 and PAP2a contribute to macrophage inflammation in response to Francisella tularensis.
Title: Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases.
LPP1 is a catabolic enzyme for lysophosphatidic acid in vivo.
Title: Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo.
Lipid phosphate phosphatase 1 (LPP-1) is presumed to regulate the balance between lipid phosphates and their dephosphorylated counterparts
Title: Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level.
there are marked differences in biochemical activity between fly Wun and mammalian lipid phosphate phosphatase (LPPs), with Wun having a narrower activity range than has been reported for the mammalian LPPs
Title: Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Mit262 (e-PCR), detects polymorphism
- UniSTS:127079

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ceramide-1-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ceramide-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol diphosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables diacylglycerol diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lipid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphatidate phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables sphingosine-1-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables sphingosine-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ceramide metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within diacylglycerol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in sphingosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sphingosine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sphingosine metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: phospholipid phosphatase 1

Names: 35 kDa PAP; hydrogen peroxide inducible protein 53; lipid phosphate phosphohydrolase 1; phosphatidate phosphohydrolase type 2a; phosphatidic acid phosphatase 2a; phosphatidic acid phosphatase type 2A

NP_032273.1

EC 3.1.3.106

EC 3.1.3.4

EC 3.6.1.75

NP_032929.1

EC 3.1.3.106

EC 3.1.3.4

EC 3.6.1.75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008247.3 → NP_032273.1 phospholipid phosphatase 1 isoform 1

See identical proteins and their annotated locations for NP_032273.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BB851583, BC061161, CD742481

Consensus CDS

CCDS26776.1

UniProtKB/Swiss-Prot

Q61469

Related

ENSMUSP00000016144.5, ENSMUST00000016144.12

Conserved Domains (1) summary

cd03384
Location:99 → 244

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
NM_008903.2 → NP_032929.1 phospholipid phosphatase 1 isoform 2

See identical proteins and their annotated locations for NP_032929.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks one exon and contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

BB851583, BY094239, CD742481, D84376

Consensus CDS

CCDS26777.1

UniProtKB/Swiss-Prot

Q61469, Q61690, Q6GT30, Q8BPB8

Related

ENSMUSP00000064423.7, ENSMUST00000070951.8

Conserved Domains (1) summary

cd03384
Location:98 → 243

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...