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    Eapp E2F-associated phosphoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299043, updated on 3-Dec-2024

    Summary

    Official Symbol
    Eappprovided by RGD
    Official Full Name
    E2F-associated phosphoproteinprovided by RGD
    Primary source
    RGD:1309624
    See related
    EnsemblRapid:ENSRNOG00000004509 AllianceGenome:RGD:1309624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309624
    Summary
    Predicted to act upstream of or within negative regulation of transcription elongation by RNA polymerase II; positive regulation of cell population proliferation; and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human EAPP (E2F associated phosphoprotein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 166.2), Thymus (RPKM 150.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Eapp in Genome Data Viewer
    Location:
    6q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (77879634..77929653, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72166486..72194357, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (75561898..75589274, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19, pseudogene 18 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134479386 Neighboring gene serine palmitoyltransferase, small subunit A Neighboring gene U6 spliceosomal RNA Neighboring gene centrin 4, pseudogene 1 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC120093206 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    E2F-associated phosphoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134987.1NP_001128459.1  E2F-associated phosphoprotein isoform 1

      See identical proteins and their annotated locations for NP_001128459.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168880
      UniProtKB/TrEMBL
      A0A8I6ADN6, B5DF09, F7EM49
      Related
      ENSRNOP00000006030.6, ENSRNOT00000006030.8
      Conserved Domains (1) summary
      pfam10238
      Location:135277
      Eapp_C; E2F-associated phosphoprotein
    2. NM_001434161.1NP_001421090.1  E2F-associated phosphoprotein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ADN6, B5DF09, F7EM49
    3. NM_001434162.1NP_001421091.1  E2F-associated phosphoprotein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HBK6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      77879634..77929653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261676.1XP_063117746.1  E2F-associated phosphoprotein isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADN6, B5DF09, F7EM49
    2. XM_006240100.5XP_006240162.1  E2F-associated phosphoprotein isoform X1

      Related
      ENSRNOP00000092269.1, ENSRNOT00000115754.2
      Conserved Domains (1) summary
      pfam10238
      Location:135277
      Eapp_C; E2F-associated phosphoprotein
    3. XM_039111974.2XP_038967902.1  E2F-associated phosphoprotein isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106729.1: Suppressed sequence

      Description
      NM_001106729.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.