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    Eef1akmt1 EEF1A lysine methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290279, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eef1akmt1provided by RGD
    Official Full Name
    EEF1A lysine methyltransferase 1provided by RGD
    Primary source
    RGD:1306762
    See related
    EnsemblRapid:ENSRNOG00000009849 AllianceGenome:RGD:1306762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    N6amt2; RGD1306762
    Summary
    Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be located in cytoplasm. Orthologous to human EEF1AKMT1 (EEF1A lysine methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 52.9), Thymus (RPKM 50.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eef1akmt1 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (35809842..35826921, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (31694284..31711367, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (37813115..37830932, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 88 Neighboring gene interleukin 17D Neighboring gene exportin 4 Neighboring gene large tumor suppressor kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. Hamey JJ, et al. Mol Cell Proteomics, 2016 Jan. PMID 26545399, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188401

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EEF1A lysine methyltransferase 1
    Names
    N(6)-adenine-specific DNA methyltransferase 2
    N-6 adenine-specific DNA methyltransferase 2 (putative)
    eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
    protein-lysine N-methyltransferase N6AMT2
    NP_001128462.1
    NP_001380751.1
    XP_038949067.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134990.3 → NP_001128462.1  EEF1A lysine methyltransferase 1

      See identical proteins and their annotated locations for NP_001128462.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A096MKD1, B5DEG5, F7FGJ4
      Related
      ENSRNOP00000068470.3, ENSRNOT00000075861.4
      Conserved Domains (1) summary
      pfam10237
      Location:49 → 161
      N6-adenineMlase; Probable N6-adenine methyltransferase

    2. NM_001393822.1 → NP_001380751.1  EEF1A lysine methyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A096MKD1, B5DEG5, F7FGJ4
      Related
      ENSRNOP00000059566.2, ENSRNOT00000064702.5
      Conserved Domains (1) summary
      pfam10237
      Location:49 → 161
      N6-adenineMlase; Probable N6-adenine methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      35809842..35826921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093139.2 → XP_038949067.1  EEF1A lysine methyltransferase 1 isoform X1

      Related
      ENSRNOP00000107908.1, ENSRNOT00000154417.1
      Conserved Domains (1) summary
      pfam10237
      Location:2 → 114
      N6-adenineMlase; Probable N6-adenine methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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