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    Rnf128 ring finger protein 128 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315911, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rnf128provided by RGD
    Official Full Name
    ring finger protein 128provided by RGD
    Primary source
    RGD:1566282
    See related
    EnsemblRapid:ENSRNOG00000055721 AllianceGenome:RGD:1566282
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566282
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of protein stability and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within negative regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and late endosome. Orthologous to human RNF128 (ring finger protein 128). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 197.3), Liver (RPKM 154.7) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Rnf128 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (107968973..108087037)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (103183643..103298431)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (110789061..110877964)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene methionyl aminopeptidase 2, pseudogene 2 Neighboring gene RPA1 related single stranded DNA binding protein, X-linked Neighboring gene TBC1 domain family member 8B Neighboring gene ribosomal protein S4, X-linked, pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC187564

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF128
    Names
    ring finger protein 128, E3 ubiquitin protein ligase
    NP_001166820.1
    XP_008771641.1
    XP_038955642.1
    XP_038955643.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173349.1NP_001166820.1  E3 ubiquitin-protein ligase RNF128 precursor

      See identical proteins and their annotated locations for NP_001166820.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167061
      UniProtKB/TrEMBL
      B2RZ84
      Related
      ENSRNOP00000071530.1, ENSRNOT00000086308.3
      Conserved Domains (2) summary
      cd02122
      Location:48193
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:275318
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      107968973..108087037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773419.4XP_008771641.1  E3 ubiquitin-protein ligase RNF128 isoform X1

      See identical proteins and their annotated locations for XP_008771641.1

      UniProtKB/TrEMBL
      B1H231
      Related
      ENSRNOP00000068929.1, ENSRNOT00000086014.3
      Conserved Domains (2) summary
      cd02122
      Location:34167
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:249292
      zf-RING_2; Ring finger domain
    2. XM_039099714.2XP_038955642.1  E3 ubiquitin-protein ligase RNF128 isoform X2

      Conserved Domains (3) summary
      COG5243
      Location:109224
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16802
      Location:116164
      RING-H2_RNF128_like; RING finger, H2 subclass, found in RING finger protein 128 (RNF128) and similar proteins
      cl28883
      Location:334
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
    3. XM_039099715.2XP_038955643.1  E3 ubiquitin-protein ligase RNF128 isoform X3

      Conserved Domains (3) summary
      COG5243
      Location:99214
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16802
      Location:106154
      RING-H2_RNF128_like; RING finger, H2 subclass, found in RING finger protein 128 (RNF128) and similar proteins
      cl28883
      Location:124
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...