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    Tnks2 tankyrase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309512, updated on 9-Dec-2024

    Summary

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    Symbol
    Tnks2provided by RGD
    Full Name
    tankyrase 2provided by RGD
    Primary source
    RGD:1305026
    See related
    EnsemblRapid:ENSRNOG00000052664 AllianceGenome:RGD:1305026
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity and enzyme binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Predicted to act upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 716.3), Brain (RPKM 372.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnks2 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243980432..244033629)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234567888..234621079)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) Unplaced Scaffold NW_007906945.1 (98838..152861)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485232 Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC120100026 Neighboring gene fibroblast growth factor binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Hsiao SJ, et al. Mol Cell Biol, 2006 Mar. PMID 16507985, Free PMC Article
    2. Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Chiang YJ, et al. Mol Cell Biol, 2006 Mar. PMID 16507984, Free PMC Article
    3. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. Kaminker PG, et al. J Biol Chem, 2001 Sep 21. PMID 11454873
    4. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Kulak O, et al. Mol Cell Biol, 2015 Jul. PMID 25939383, Free PMC Article
    5. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. Yang M, et al. FEBS J, 2011 Apr. PMID 21251231, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein auto-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein poly-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    poly [ADP-ribose] polymerase tankyrase-2
    Names
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
    tankyrase-2-like
    NP_001101077.2
    XP_038936561.1
    XP_038936562.1
    XP_063121260.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107607.2 → NP_001101077.2  poly [ADP-ribose] polymerase tankyrase-2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JTB0
      Related
      ENSRNOP00000068637.2, ENSRNOT00000079808.3
      Conserved Domains (8) summary
      cd09524
      Location:871 → 936
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      smart00454
      Location:877 → 933
      SAM; Sterile alpha motif
      cd00204
      Location:518 → 643
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01438
      Location:938 → 1160
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      pfam00644
      Location:952 → 1155
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam12796
      Location:530 → 622
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:28 → 78
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:528 → 556
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      243980432..244033629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080634.2 → XP_038936562.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

      UniProtKB/TrEMBL
      D3ZRP5
      Related
      ENSRNOP00000073499.2, ENSRNOT00000085497.3
      Conserved Domains (5) summary
      PTZ00322
      Location:27 → 113
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02876
      Location:73 → 458
      PHA02876; ankyrin repeat protein; Provisional
      cd09524
      Location:808 → 873
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      cd01438
      Location:875 → 1097
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      sd00045
      Location:528 → 556
      ANK; ANK repeat [structural motif]

    2. XM_039080633.2 → XP_038936561.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

      Related
      ENSRNOP00000098656.1, ENSRNOT00000132955.1
      Conserved Domains (5) summary
      cd09524
      Location:814 → 879
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      PHA03095
      Location:437 → 745
      PHA03095; ankyrin-like protein; Provisional
      cd01438
      Location:881 → 1103
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      sd00045
      Location:471 → 499
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:364 → 415
      Ank_5; Ankyrin repeats (many copies)

    3. XM_063265190.1 → XP_063121260.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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