Chuk component of inhibitor of nuclear factor kappa B kinase complex [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chukprovided by RGD
Official Full Name: component of inhibitor of nuclear factor kappa B kinase complexprovided by RGD
Primary source: RGD:1306661
See related: EnsemblRapid:ENSRNOG00000022485 AllianceGenome:RGD:1306661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ikka; Ikbka
Summary: Predicted to enable several functions, including protein dimerization activity; scaffold protein binding activity; and transferrin receptor binding activity. Predicted to contribute to IkappaB kinase activity. Involved in several processes, including response to acetate; response to cholecystokinin; and response to hydroperoxide. Part of IkappaB kinase complex. Used to study muscular atrophy. Biomarker of colitis. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 214.9), Liver (RPKM 178.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252908748..252944273, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242959539..242995066, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263848829..263884354, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potential function of IKKalpha in gastric precancerous lesion via mediating Maspin.
Title: The potential function of IKKα in gastric precancerous lesion via mediating Maspin.
Altogether, the results suggest that in the absence of excitatory conditions, constitutive IKK activity at the PSD regulates CYLD and maintains basal levels of K63-linkage specific deubiquitination at the synapse.
Title: IKK regulates the deubiquitinase CYLD at the postsynaptic density.
Increased IKKalpha/beta and JNK serine phosphorylation may contribute to increasing IRS-1 serine phosphorylation, while concurrent co-localization of SOCS-3 with both IR-beta and IRS-1 may prevent IRS-1 from interacting with IR-beta; these 2 mechanisms may independently contribute to impairing insulin-stimulated PI3-K activation in the skeletal muscle of the obese Zucker rat.
Title: Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKKα/β phosphorylation are increased in obese Zucker rat skeletal muscle.
High-fat feeding increases IKKalpha phosphorylation in skeletal muscle.
Title: High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKalpha/beta phosphorylation and decreases PI-3 kinase activity in muscle.
both IKKalpha and IKKbeta are necessary and sufficient for physiological muscle atrophy.
Title: The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy.
canonical IKKbeta-dependent NF-kappaB activation is inhibited by peroxynitrite, which also activates NF-kappaB-inducing kinase and IKKalpha phosphorylation
Title: Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to IkappaB kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IkappaB kinase activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of an epithelial sheet	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to acetate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cholecystokinin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hydroperoxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle contraction	IEP Inferred from Expression Pattern more info	PubMed
involved_in striated muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CD40 receptor complex	ISO Inferred from Sequence Orthology more info
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IkappaB kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of IkappaB kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit alpha

Names: conserved helix-loop-helix ubiquitous kinase

NP_001101058.1

EC 2.7.11.10

XP_063120675.1

EC 2.7.11.10

XP_063120678.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107588.1 → NP_001101058.1 inhibitor of nuclear factor kappa-B kinase subunit alpha

See identical proteins and their annotated locations for NP_001101058.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/TrEMBL

A0A8I6ANR6, A6JHE8

Related

ENSRNOP00000034134.5, ENSRNOT00000030782.6

Conserved Domains (3) summary

smart00220
Location:15 → 287

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14039
Location:21 → 309

STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

pfam12179
Location:709 → 743

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain