Foxf1 forkhead box F1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxf1provided by MGI
Official Full Name: forkhead box F1provided by MGI
Primary source: MGI:MGI:1347470
See related: Ensembl:ENSMUSG00000042812 AllianceGenome:MGI:1347470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hfh8; HFH-8; FREAC1; Foxf1a; Freac-1
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mesenchyme morphogenesis; regulation of transcription by RNA polymerase II; and respiratory system development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and genitourinary system. Used to study persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Orthologous to human FOXF1 (forkhead box F1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 158.2), colon adult (RPKM 48.1) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 70.31 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (121811100..121814883)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (121084386..121088154)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4.
Title: FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4.
Identification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasia.
Title: Identification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasia.
FOXF1 reverses lung fibroblasts transdifferentiation via inhibiting TGF-beta/SMAD2/3 pathway in silica-induced pulmonary fibrosis.
Title: FOXF1 reverses lung fibroblasts transdifferentiation via inhibiting TGF-β/SMAD2/3 pathway in silica-induced pulmonary fibrosis.
Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension.
Title: Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension.
FOXF1 Regulates Alveolar Epithelial Morphogenesis through Transcriptional Activation of Mesenchymal WNT5A.
Title: FOXF1 Regulates Alveolar Epithelial Morphogenesis through Transcriptional Activation of Mesenchymal WNT5A.
The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFbeta signaling pathways to drive tongue organogenesis.
Title: The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis.
Transcription factor FOXF1 identifies compartmentally distinct mesenchymal cells with a role in lung allograft fibrogenesis.
Title: Transcription factor FOXF1 identifies compartmentally distinct mesenchymal cells with a role in lung allograft fibrogenesis.
FOXF1 mutations identified in 28 subjects with ACDMPV. Foxf1WT/S52F knock-in mice recapitulated histopathologic findings in ACDMPV infants. The S52F FOXF1 mutation disrupted STAT3-FOXF1 protein-protein interactions and inhibited transcription of Stat3 STAT3 signaling and endothelial proliferation were reduced in Foxf1WT/S52F mice and human ACDMPV lungs.
Title: The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia.
Knockout of Foxf1 and Foxf2 together, but not alone, from mouse smooth muscle resulted in delayed liquid gastric emptying
Title: Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice.
FOXF1 deletion increases myofibroblast invasion and collagen secretion and promotes a switch from N-cadherin (CDH2) to Cadherin-11 (CDH11), which is a critical step in the acquisition of the pro-fibrotic phenotype. FOXF1 directly binds to Cdh2 and Cdh11 promoters and differentially regulates transcription of these genes.
Title: FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI450827 (e-PCR)
- UniSTS:164393

NoName (e-PCR)
- UniSTS:548419

NoName (e-PCR)
- UniSTS:548420

Foxf1a (e-PCR), detects polymorphism
- UniSTS:531336

Foxf1a (e-PCR), detects polymorphism
- UniSTS:526994

Foxf1a (e-PCR), detects polymorphism
- UniSTS:547225

NoName (e-PCR)
- UniSTS:236022

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in cardiac left ventricle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in ductus arteriosus closure	IEA Inferred from Electronic Annotation more info
involved_in ductus arteriosus closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic ectodermal digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic ectodermal digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardial cushion development	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation involved in mammary gland alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral mesodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung lobe morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung vasculature development	IEA Inferred from Electronic Annotation more info
involved_in lung vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchyme migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesodermal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mesodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IEA Inferred from Electronic Annotation more info
involved_in midgut development	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of a branching structure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pancreas development	IEA Inferred from Electronic Annotation more info
involved_in pancreas development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in respiratory tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within right lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trachea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trachea development	ISO Inferred from Sequence Orthology more info
involved_in ureter development	IEA Inferred from Electronic Annotation more info
involved_in ureter development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in venous blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in venous blood vessel development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: forkhead box protein F1

Names: HNF-3/forkhead homolog 8; forkhead box F1a; forkhead-related protein FKHL5; forkhead-related transcription factor 1; hepatocyte nuclear factor 3 forkhead homolog 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.