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    Rnh1 ribonuclease/angiogenin inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 107702, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnh1provided by MGI
    Official Full Name
    ribonuclease/angiogenin inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1195456
    See related
    Ensembl:ENSMUSG00000038650 AllianceGenome:MGI:1195456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNH
    Summary
    Predicted to enable ribonuclease inhibitor activity. Predicted to be involved in cell migration; regulation of Arp2/3 complex-mediated actin nucleation; and regulation of angiogenesis. Predicted to be located in cytosol. Predicted to be part of angiogenin-PRI complex. Predicted to be active in several cellular components, including lamellipodium; nucleoplasm; and plasma membrane. Is expressed in bladder; blood; embryo; pancreas; and yolk sac. Orthologous to human RNH1 (ribonuclease/angiogenin inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 94.0), adrenal adult (RPKM 89.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnh1 in Genome Data Viewer
    Location:
    7 F5; 7 86.44 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140740239..140752764, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141160326..141172851, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E451 Neighboring gene predicted gene, 33560 Neighboring gene phosphatidylserine synthase 2 Neighboring gene STARR-positive B cell enhancer ABC_E8222 Neighboring gene STARR-positive B cell enhancer ABC_E9715 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene predicted gene, 51459 Neighboring gene predicted gene, 22019

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolution of ribonuclease inhibitor by exon duplication. Haigis MC, et al. Mol Biol Evol, 2002 Jun. PMID 12032252
    2. Identification of a novel angiogenin inhibitor 1 and its association with hyaluronidase of Streptococcus suis serotype 2. Wu T, et al. Microb Pathog, 2010 Jul-Aug. PMID 20307645
    3. LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity. Bombaci G, et al. Life Sci Alliance, 2022 Jun. PMID 35256513, Free PMC Article
    4. Expression of mRNAs of pancreatic and L type RNase inhibitors as a function of age in different tissues of SAMP8 and BDF1 mice. Semsei I, et al. Mech Ageing Dev, 1997 Sep. PMID 9234238
    5. Functional evolution of ribonuclease inhibitor: insights from birds and reptiles. Lomax JE, et al. J Mol Biol, 2014 Aug 26. PMID 24941155, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New link between RNH1 and E2F1: regulates the development of lung adenocarcinoma.
      Title: New link between RNH1 and E2F1: regulates the development of lung adenocarcinoma.
    2. RNH1 binds to the 40S subunit of ribosomes and facilitates polysome formation on Gata1 mRNA to confer transcript-specific translation.
      Title: Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
    3. X-ray crystallographic analysis of RNH1 from mouse, bovine and chicken binding to RNase reveals two residues that appear to contribute to the differential binding affinity.
      Title: Functional evolution of ribonuclease inhibitor: insights from birds and reptiles.
    4. Mouse angiogenin inhibitor 1 interacts with hylA of Streptococcus suis.
      Title: Identification of a novel angiogenin inhibitor 1 and its association with hyaluronidase of Streptococcus suis serotype 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribonuclease inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of angiogenin-PRI complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of angiogenin-PRI complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172100.1 → NP_001165571.1  ribonuclease inhibitor isoform a

      See identical proteins and their annotated locations for NP_001165571.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a), which is shorter than isoform b.
      Source sequence(s)
      AK141351, BY114445, BY574079
      Consensus CDS
      CCDS22002.1
      UniProtKB/Swiss-Prot
      Q91VI7, Q924P4
      UniProtKB/TrEMBL
      Q3UM23
      Related
      ENSMUSP00000133061.2, ENSMUST00000167493.9
      Conserved Domains (3) summary
      smart00368
      Location:335 → 362
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:1 → 320
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:2 → 24
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_001172101.1 → NP_001165572.1  ribonuclease inhibitor isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' splice pattern and uses a distinct start codon, compared to variant 1. The resulting isoform (b) has a longer N-terminus, compared to isoform a.
      Source sequence(s)
      AK141351, BY085526, BY574079
      Consensus CDS
      CCDS85455.1
      UniProtKB/TrEMBL
      A0A1B0GSG5, Q3UM23
      Related
      ENSMUSP00000147928.2, ENSMUST00000210314.2
      Conserved Domains (4) summary
      smart00368
      Location:371 → 398
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      COG4886
      Location:46 → 361
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:37 → 356
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:38 → 60
      LRR_RI; leucine-rich repeat [structural motif]

    3. NM_145135.3 → NP_660117.2  ribonuclease inhibitor isoform a

      See identical proteins and their annotated locations for NP_660117.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a), which is shorter than isoform b.
      Source sequence(s)
      AK141351, BM946973, BY574079
      Consensus CDS
      CCDS22002.1
      UniProtKB/Swiss-Prot
      Q91VI7, Q924P4
      UniProtKB/TrEMBL
      Q3UM23
      Related
      ENSMUSP00000101651.4, ENSMUST00000106033.5
      Conserved Domains (3) summary
      smart00368
      Location:335 → 362
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:1 → 320
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:2 → 24
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140740239..140752764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VI7.1 GenPept UniProtKB/Swiss-Prot:Q91VI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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