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    Lrrc40 leucine rich repeat containing 40 [ Mus musculus (house mouse) ]

    Gene ID: 67144, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc40provided by MGI
    Official Full Name
    leucine rich repeat containing 40provided by MGI
    Primary source
    MGI:MGI:1914394
    See related
    Ensembl:ENSMUSG00000063052 AllianceGenome:MGI:1914394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610040E16Rik
    Summary
    Predicted to be involved in intracellular signal transduction. Is expressed in genitourinary system. Orthologous to human LRRC40 (leucine rich repeat containing 40). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.4), placenta adult (RPKM 9.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc40 in Genome Data Viewer
    Location:
    3 H4; 3 81.65 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157742340..157772727)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (158036682..158067090)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7952 Neighboring gene STARR-positive B cell enhancer ABC_E8807 Neighboring gene ankyrin repeat domain 13c Neighboring gene STARR-seq mESC enhancer starr_09389 Neighboring gene STARR-positive B cell enhancer ABC_E2684 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157723907-157724208 Neighboring gene STARR-positive B cell enhancer ABC_E11232 Neighboring gene STARR-positive B cell enhancer ABC_E7953 Neighboring gene serine and arginine-rich splicing factor 11 Neighboring gene leucine rich repeat containing 7 Neighboring gene STARR-seq mESC enhancer starr_09391 Neighboring gene STARR-seq mESC enhancer starr_09392 Neighboring gene STARR-seq mESC enhancer starr_09393 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    2. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    3. Oct4 links multiple epigenetic pathways to the pluripotency network. Ding J, et al. Cell Res, 2012 Jan. PMID 22083510, Free PMC Article
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289524.2 → NP_001276453.1  leucine-rich repeat-containing protein 40 isoform b

      See identical proteins and their annotated locations for NP_001276453.1

      Status: VALIDATED

      Source sequence(s)
      AC145301
      UniProtKB/TrEMBL
      Q78KN5
      Conserved Domains (4) summary
      cd00116
      Location:25 → 150
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:349 → 360
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:27 → 48
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:47 → 106
      LRR_8; Leucine rich repeat

    2. NM_001289525.2 → NP_001276454.1  leucine-rich repeat-containing protein 40 isoform b

      See identical proteins and their annotated locations for NP_001276454.1

      Status: VALIDATED

      Source sequence(s)
      AC145301
      UniProtKB/TrEMBL
      Q78KN5
      Conserved Domains (4) summary
      cd00116
      Location:25 → 150
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:349 → 360
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:27 → 48
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:47 → 106
      LRR_8; Leucine rich repeat

    3. NM_001359763.2 → NP_001346692.1  leucine-rich repeat-containing protein 40 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC145301
      Conserved Domains (3) summary
      sd00031
      Location:444 → 455
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:7 → 29
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:20 → 454
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    4. NM_001426724.1 → NP_001413653.1  leucine-rich repeat-containing protein 40 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC145301

    5. NM_001426725.1 → NP_001413654.1  leucine-rich repeat-containing protein 40 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC145301

    6. NM_001426726.1 → NP_001413655.1  leucine-rich repeat-containing protein 40 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC145301

    7. NM_001426727.1 → NP_001413656.1  leucine-rich repeat-containing protein 40 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC145301

    8. NM_001426728.1 → NP_001413657.1  leucine-rich repeat-containing protein 40 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC145301
      UniProtKB/TrEMBL
      Q78KN5

    9. NM_001426730.1 → NP_001413659.1  leucine-rich repeat-containing protein 40 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC145301
      UniProtKB/TrEMBL
      Q78KN5

    10. NM_001426731.1 → NP_001413660.1  leucine-rich repeat-containing protein 40 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC145301
      UniProtKB/TrEMBL
      Q78KN5

    11. NM_001426732.1 → NP_001413661.1  leucine-rich repeat-containing protein 40 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC145301
      UniProtKB/TrEMBL
      Q78KN5

    12. NM_001426733.1 → NP_001413662.1  leucine-rich repeat-containing protein 40 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC145301

    13. NM_001426734.1 → NP_001413663.1  leucine-rich repeat-containing protein 40 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC145301

    14. NM_001426735.1 → NP_001413664.1  leucine-rich repeat-containing protein 40 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC145301

    15. NM_001426736.1 → NP_001413665.1  leucine-rich repeat-containing protein 40 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC145301

    16. NM_001426737.1 → NP_001413666.1  leucine-rich repeat-containing protein 40 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC145301

    17. NM_024194.7 → NP_077156.2  leucine-rich repeat-containing protein 40 isoform a

      See identical proteins and their annotated locations for NP_077156.2

      Status: VALIDATED

      Source sequence(s)
      AC145301
      Consensus CDS
      CCDS17935.1
      UniProtKB/Swiss-Prot
      Q78WQ9, Q8BS83, Q9CRC8
      UniProtKB/TrEMBL
      A0A0R4J0W6
      Related
      ENSMUSP00000071956.4, ENSMUST00000072080.10
      Conserved Domains (4) summary
      cd00116
      Location:101 → 368
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:567 → 578
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:84 → 106
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:129 → 186
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      157742340..157772727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRC8.2 GenPept UniProtKB/Swiss-Prot:Q9CRC8

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