Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc13a3provided by MGI
Official Full Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3provided by MGI
Primary source: MGI:MGI:2149635
See related: Ensembl:ENSMUSG00000018459 AllianceGenome:MGI:2149635
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NaC3; NaDC3; SDCT2; NaDC-3
Summary: Enables high-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transmembrane transport. Acts upstream of or within dicarboxylic acid transport. Located in membrane. Is expressed in several structures, including central nervous system; esophagus; male reproductive gland or organ; metanephros; and retina. Orthologous to human SLC13A3 (solute carrier family 13 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 238.1), liver E18 (RPKM 17.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.54 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (165247215..165315117, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (165405295..165473197, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy.
Title: Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy.
Genetic or pharmacological inhibition of SLUG or forced expression of Slc13a3 suppresses the growth of human AML cells.
Title: Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway.
demonstrate the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations
Title: 3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit288 (e-PCR), detects polymorphism
- UniSTS:129174

Slc13a3 (e-PCR), detects polymorphism
- UniSTS:545986

D2S2063 (e-PCR)
- UniSTS:153839

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alpha-ketoglutarate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables citrate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dicarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables glutathione transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glutathione transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity sodium:dicarboxylate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables modified amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables organic acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables sodium:dicarboxylate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:dicarboxylate symporter activity	ISO Inferred from Sequence Orthology more info
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	IEA Inferred from Electronic Annotation more info
involved_in aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in citrate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in citrate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dicarboxylic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dicarboxylic acid transport	ISO Inferred from Sequence Orthology more info
involved_in glutathione transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glutathione transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in succinate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in succinate transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Na(+)/dicarboxylate cotransporter 3

Names: Na(+)-coupled carboxylate transporter 3; mNaDC3; sodium-dependent high-affinity dicarboxylate transporter 2; solute carrier family 13 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054055.2 → NP_473396.1 Na(+)/dicarboxylate cotransporter 3

See identical proteins and their annotated locations for NP_473396.1

Status: PROVISIONAL

Source sequence(s)

AL591064

Consensus CDS

CCDS17081.1

UniProtKB/Swiss-Prot

Q91Y63

UniProtKB/TrEMBL

A2A4U9, Q3UUJ6

Related

ENSMUSP00000029208.9, ENSMUST00000029208.15

Conserved Domains (2) summary

cd01115
Location:42 → 556

SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...

TIGR00785
Location:31 → 565

dass; anion transporter