Lars1 leucyl-tRNA synthetase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lars1provided by MGI
Official Full Name: leucyl-tRNA synthetase 1provided by MGI
Primary source: MGI:MGI:1913808
See related: Ensembl:ENSMUSG00000024493 AllianceGenome:MGI:1913808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lars; leuRS; 2310045K21Rik; 3110009L02Rik
Summary: Enables leucine-tRNA ligase activity. Involved in leucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.9), placenta adult (RPKM 10.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 22.37 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (42335363..42395302, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (42202298..42262237, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy.
Title: Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy.
this study provides evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage
Title: Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.
leucyl-tRNA synthetase has a nontranslational function in regulating myogenic differentiation and skeletal muscle regeneration
Title: Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration.
High LARS expression is associated with abdominal aortic aneurysm.
Title: Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lars (e-PCR), detects polymorphism
- UniSTS:546836

AW536573 (e-PCR)
- UniSTS:181113

AU015140 (e-PCR)
- UniSTS:209377

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables aminoacyl-tRNA editing activity	ISO Inferred from Sequence Orthology more info
enables aminoacyl-tRNA editing activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables glutamine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables leucine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leucine-tRNA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables leucine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables leucine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-leucine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-leucine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leucine starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in glutaminyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in glutaminyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in leucyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leucyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in leucyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine--tRNA ligase, cytoplasmic

Names: leucyl-tRNA synthetase, cytoplasmic

NP_598898.2

EC 6.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134137.3 → NP_598898.2 leucine--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_598898.2

Status: VALIDATED

Source sequence(s)

BB652360, BC052715, BE989557

Consensus CDS

CCDS37796.1

UniProtKB/Swiss-Prot

Q8BKW9, Q8BMJ2

UniProtKB/TrEMBL

Q6ZPT2, Q7TSZ3

Related

ENSMUSP00000095197.4, ENSMUST00000097590.5

Conserved Domains (5) summary

cd07959
Location:757 → 876

Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases

cd00812
Location:527 → 759

LeuRS_core; catalytic core domain of leucyl-tRNA synthetases

PLN02959
Location:3 → 1064

PLN02959; aminoacyl-tRNA ligase

cl00015
Location:47 → 231

nt_trans; nucleotidyl transferase superfamily

cl12020
Location:858 → 907

Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains