Cdc42ep1 CDC42 effector protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc42ep1provided by MGI
Official Full Name: CDC42 effector protein 1provided by MGI
Primary source: MGI:MGI:1929763
See related: Ensembl:ENSMUSG00000049521 AllianceGenome:MGI:1929763
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CEP1; Borg5; MSE55; 1810058K22Rik
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within Rho protein signal transduction. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human CDC42EP1 (CDC42 effector protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 172.0), subcutaneous fat pad adult (RPKM 83.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78726847..78735102)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (78842647..78850902)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Borg5 is required for angiogenesis by regulating persistent directional migration of the cardiac microvascular endothelial cells.
Title: Borg5 is required for angiogenesis by regulating persistent directional migration of the cardiac microvascular endothelial cells.
report that differentiation of embryonic stem cells toward trophectoderm is accompanied by enhanced actin protrusion and cell motility that require upregulation of Borg5.
Title: A role for borg5 during trophectoderm differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lgals2 (e-PCR), detects polymorphism
- UniSTS:516140

AI324147 (e-PCR)
- UniSTS:180789

AA980734 (e-PCR)
- UniSTS:180790

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pseudopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pseudopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cdc42 effector protein 1

Names: CDC42 effector protein (Rho GTPase binding) 1; binder of Rho GTPase 5; binder of Rho GTPases 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027219.3 → NP_081495.1 cdc42 effector protein 1

See identical proteins and their annotated locations for NP_081495.1

Status: PROVISIONAL

Source sequence(s)

AL592169

Consensus CDS

CCDS27624.1

UniProtKB/Swiss-Prot

Q91W92, Q9D8M1

UniProtKB/TrEMBL

A0A0R4J0S1

Related

ENSMUSP00000060930.2, ENSMUST00000059619.3

Conserved Domains (2) summary

pfam14957
Location:117 → 230

BORG_CEP; Cdc42 effector

cl00113
Location:37 → 64

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...