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    APE2 Glucose-6-phosphate/phosphate translocator-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834652, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APE2
    Official Full Name
    Glucose-6-phosphate/phosphate translocator-like protein
    Primary source
    TAIR:AT5G46110
    Locus tag
    AT5G46110
    See related
    Araport:AT5G46110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACCLIMATION OF PHOTOSYNTHESIS TO ENVIRONMENT 2; ACCLIMATION OF PHOTOSYNTHESIS TO ENVIRONMENT 2; phosphate translocator; TPT; triose-phosphate ⁄
    Summary
    Encodes a chloroplast triose phosphate / 3-phosphoglycerate translocator that transports triose phosphates derived from the Calvin cycle in the stroma to the cytosol for use in sucrose synthesis and other biosynthetic processes. A tpt mutant has altered acclimation responses.
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    Genomic context

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    See APE2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (18697235..18700900)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene transmembrane protein, putative (DUF679) Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene tRNA-Pro Neighboring gene uncharacterized protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of mutants of Arabidopsis defective in acclimation of photosynthesis to the light environment. Walters RG, et al. Plant Physiol, 2003 Feb. PMID 12586872, Free PMC Article
    2. An Arabidopsis thaliana knock-out mutant of the chloroplast triose phosphate/phosphate translocator is severely compromised only when starch synthesis, but not starch mobilisation is abolished. Schneider A, et al. Plant J, 2002 Dec. PMID 12472685
    3. Overexpression of the triose phosphate translocator (TPT) complements the abnormal metabolism and development of plastidial glycolytic glyceraldehyde-3-phosphate dehydrogenase mutants. Flores-Tornero M, et al. Plant J, 2017 Mar. PMID 27984670
    4. Requirement for abasic endonuclease gene homologues in Arabidopsis seed development. Murphy TM, et al. PLoS One, 2009. PMID 19172180, Free PMC Article
    5. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TPT expression under the control of both promoters complemented the vegetative developmental defects and metabolic disorders of the GAPCp double mutants (gapcp1gapcp2).
      Title: Overexpression of the triose phosphate translocator (TPT) complements the abnormal metabolism and development of plastidial glycolytic glyceraldehyde-3-phosphate dehydrogenase mutants.
    2. plants with knock-out mutations in any one of Ape1L, Ape2, or Arp show no apparent differences from wild type in growth rate, growth habit, and fertility
      Title: Requirement for abasic endonuclease gene homologues in Arabidopsis seed development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036940.1
    NM_001085251.1
    NM_123979.2
    NM_180807.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphoglycerate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triose-phosphate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triose-phosphate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphoglycerate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in photosynthetic acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triose phosphate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within triose phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Glucose-6-phosphate/phosphate translocator-like protein
    NP_001032017.1
    • ACCLIMATION OF PHOTOSYNTHESIS TO ENVIRONMENT 2 (APE2); FUNCTIONS IN: antiporter activity; INVOLVED IN: transport; LOCATED IN: chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tpt phosphate/phosphoenolpyruvate translocator (InterPro:IPR004696), Protein of unknown function DUF250 (InterPro:IPR004853); BEST Arabidopsis thaliana protein match is: glucose 6-phosphate/phosphate translocator 1 (TAIR:AT5G54800.1); Has 2191 Blast hits to 2189 proteins in 289 species: Archae - 0; Bacteria - 65; Metazoa - 435; Fungi - 400; Plants - 1036; Viruses - 0; Other Eukaryotes - 255 (source: NCBI BLink).
    NP_001078720.1
    • ACCLIMATION OF PHOTOSYNTHESIS TO ENVIRONMENT 2 (APE2); FUNCTIONS IN: antiporter activity; INVOLVED IN: transport; LOCATED IN: chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF250 (InterPro:IPR004853), Tpt phosphate/phosphoenolpyruvate translocator (InterPro:IPR004696); BEST Arabidopsis thaliana protein match is: glucose 6-phosphate/phosphate translocator 1 (TAIR:AT5G54800.1); Has 2560 Blast hits to 2558 proteins in 418 species: Archae - 2; Bacteria - 316; Metazoa - 499; Fungi - 419; Plants - 1040; Viruses - 0; Other Eukaryotes - 284 (source: NCBI BLink).
    NP_568655.2
    • ACCLIMATION OF PHOTOSYNTHESIS TO ENVIRONMENT 2 (APE2); FUNCTIONS IN: antiporter activity; INVOLVED IN: transport; LOCATED IN: chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF250 (InterPro:IPR004853), Tpt phosphate/phosphoenolpyruvate translocator (InterPro:IPR004696); BEST Arabidopsis thaliana protein match is: glucose 6-phosphate/phosphate translocator 1 (TAIR:AT5G54800.1); Has 2495 Blast hits to 2493 proteins in 411 species: Archae - 0; Bacteria - 311; Metazoa - 491; Fungi - 411; Plants - 1009; Viruses - 0; Other Eukaryotes - 273 (source: NCBI BLink).
    NP_851138.1
    • ACCLIMATION OF PHOTOSYNTHESIS TO ENVIRONMENT 2 (APE2); FUNCTIONS IN: antiporter activity; INVOLVED IN: transport; LOCATED IN: chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tpt phosphate/phosphoenolpyruvate translocator (InterPro:IPR004696), Protein of unknown function DUF250 (InterPro:IPR004853); BEST Arabidopsis thaliana protein match is: glucose 6-phosphate/phosphate translocator 1 (TAIR:AT5G54800.1); Has 2548 Blast hits to 2546 proteins in 418 species: Archae - 2; Bacteria - 319; Metazoa - 501; Fungi - 418; Plants - 1031; Viruses - 0; Other Eukaryotes - 277 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18697235..18700900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180807.2 → NP_851138.1  Glucose-6-phosphate/phosphate translocator-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851138.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56WK8, Q8LB04, Q93ZM3, Q9FNL1, Q9ZSR7
      UniProtKB/TrEMBL
      A0A178UCH2, A0A5S9YBI1
      Conserved Domains (1) summary
      TIGR00817
      Location:106 → 404
      tpt; Tpt phosphate/phosphoenolpyruvate translocator

    2. NM_123979.2 → NP_568655.2  Glucose-6-phosphate/phosphate translocator-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568655.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A219HYB6
      Conserved Domains (2) summary
      TIGR00817
      Location:1 → 291
      tpt; Tpt phosphate/phosphoenolpyruvate translocator
      cl23754
      Location:136 → 282
      EamA; EamA-like transporter family

    3. NM_001085251.1 → NP_001078720.1  Glucose-6-phosphate/phosphate translocator-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078720.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCH2, A0A219I0W9
      Conserved Domains (2) summary
      TIGR00817
      Location:106 → 404
      tpt; Tpt phosphate/phosphoenolpyruvate translocator
      cl23754
      Location:249 → 395
      EamA; EamA-like transporter family

    4. NM_001036940.1 → NP_001032017.1  Glucose-6-phosphate/phosphate translocator-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCH2, A0A219HZH3
      Conserved Domains (1) summary
      TIGR00817
      Location:106 → 393
      tpt; Tpt phosphate/phosphoenolpyruvate translocator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZSR7.1

    Gene LinkOut

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