U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Slc12a2 solute carrier family 12, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 20496, updated on 13-Jan-2025

    Summary

    Official Symbol
    Slc12a2provided by MGI
    Official Full Name
    solute carrier family 12, member 2provided by MGI
    Primary source
    MGI:MGI:101924
    See related
    Ensembl:ENSMUSG00000024597 AllianceGenome:MGI:101924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BSC2; Nkcc1; mBSC2; sy-ns; mNKCC1; 9330166H04Rik
    Summary
    Enables potassium ion transmembrane transporter activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to potassium ion; and inorganic ion transmembrane transport. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; mammary gland duct morphogenesis; and regulation of secretion by cell. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; lung; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78 and middle cerebral artery infarction. Orthologous to human SLC12A2 (solute carrier family 12 member 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in mammary gland adult (RPKM 43.3), colon adult (RPKM 19.3) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc12a2 in Genome Data Viewer
    Location:
    18 D3; 18 32.15 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (58011505..58079893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (57878512..57946821)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44692 Neighboring gene predicted gene, 19519 Neighboring gene predicted gene, 35751 Neighboring gene STARR-seq mESC enhancer starr_44694 Neighboring gene STARR-positive B cell enhancer mm9_chr18:58136200-58136501 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:58168874-58169112 Neighboring gene fibrillin 2 Neighboring gene STARR-seq mESC enhancer starr_44697 Neighboring gene STARR-seq mESC enhancer starr_44698 Neighboring gene predicted gene, 41741

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp90 protein binding  
    enables ammonium channel activity  
    enables ammonium channel activity  
    enables chloride:monoatomic cation symporter activity  
    enables metal ion binding  
    enables metal ion transmembrane transporter activity  
    enables potassium ion transmembrane transporter activity PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein-folding chaperone binding  
    enables sodium:potassium:chloride symporter activity  
    enables sodium:potassium:chloride symporter activity PubMed 
    enables sodium:potassium:chloride symporter activity  
    Items 1 - 25 of 43
    Process Evidence Code Pubs
    involved_in T cell chemotaxis PubMed 
    involved_in T cell chemotaxis  
    involved_in ammonium transmembrane transport  
    involved_in ammonium transmembrane transport  
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis PubMed 
    involved_in cell volume homeostasis  
    acts_upstream_of_or_within cell volume homeostasis PubMed 
    involved_in cellular response to chemokine PubMed 
    involved_in cellular response to chemokine  
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to potassium ion PubMed 
    involved_in chloride ion homeostasis  
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport PubMed 
    involved_in chloride transport  
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound PubMed 
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway  
    involved_in hyperosmotic response  
    involved_in inorganic anion import across plasma membrane PubMed 
    involved_in inorganic cation import across plasma membrane  
    acts_upstream_of_or_within intracellular chloride ion homeostasis PubMed 
    acts_upstream_of_or_within intracellular potassium ion homeostasis PubMed 
    acts_upstream_of_or_within intracellular sodium ion homeostasis PubMed 
    acts_upstream_of_or_within maintenance of blood-brain barrier PubMed 
    acts_upstream_of_or_within mammary duct terminal end bud growth PubMed 
    acts_upstream_of_or_within multicellular organism growth PubMed 
    acts_upstream_of_or_within negative regulation of vascular wound healing PubMed 
    acts_upstream_of_or_within positive regulation of aspartate secretion PubMed 
    involved_in positive regulation of cell volume  
    involved_in potassium ion homeostasis  
    involved_in potassium ion import across plasma membrane  
    involved_in potassium ion import across plasma membrane PubMed 
    involved_in potassium ion transport  
    acts_upstream_of_or_within regulation of matrix metallopeptidase secretion PubMed 
    acts_upstream_of_or_within regulation of spontaneous synaptic transmission PubMed 
    acts_upstream_of_or_within regulation of spontaneous synaptic transmission PubMed 
    acts_upstream_of_or_within regulation of spontaneous synaptic transmission  
    involved_in sodium ion homeostasis  
    involved_in sodium ion import across plasma membrane PubMed 
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transport  
    involved_in transepithelial ammonium transport  
    involved_in transepithelial chloride transport  
    Items 1 - 25 of 43
    Component Evidence Code Pubs
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in basal plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in cell body PubMed 
    located_in cell periphery PubMed 
    located_in cell periphery  
    located_in cell projection PubMed 
    located_in cytoplasmic vesicle membrane  
    located_in lateral plasma membrane  
    located_in neuron projection  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    solute carrier family 12 member 2
    Names
    Na-K-2Cl cotransporter 1
    basolateral Na-K-Cl symporter
    bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
    bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
    sodium/potassium/chloride cotransporters
    sodium/potassium/chloride transporters

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009194.3NP_033220.2  solute carrier family 12 member 2

      Status: VALIDATED

      Source sequence(s)
      AC127678, CJ172807, CN711123, U13174
      Consensus CDS
      CCDS37826.1
      UniProtKB/Swiss-Prot
      E9PYU3, P55012
      UniProtKB/TrEMBL
      E9QM38
      Related
      ENSMUSP00000111023.3, ENSMUST00000115366.3
      Conserved Domains (3) summary
      TIGR00930
      Location:2101206
      2a30; K-Cl cotransporter
      pfam03522
      Location:7951206
      SLC12; Solute carrier family 12
      pfam08403
      Location:196257
      AA_permease_N; Amino acid permease N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      58011505..58079893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525732.4XP_006525795.1  solute carrier family 12 member 2 isoform X1

      UniProtKB/Swiss-Prot
      E9PYU3, P55012
      Conserved Domains (2) summary
      PRK07764
      Location:374
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      TIGR00930
      Location:2101190
      2a30; K-Cl cotransporter

    RNA

    1. XR_001782352.2 RNA Sequence

    External link. Please review our privacy policy.