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    METTL22 methyltransferase 22, Kin17 lysine [ Homo sapiens (human) ]

    Gene ID: 79091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    METTL22provided by HGNC
    Official Full Name
    methyltransferase 22, Kin17 lysineprovided by HGNC
    Primary source
    HGNC:HGNC:28368
    See related
    Ensembl:ENSG00000067365 MIM:615261; AllianceGenome:HGNC:28368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C16orf68
    Summary
    This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in testis (RPKM 2.7), endometrium (RPKM 1.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See METTL22 in Genome Data Viewer
    Location:
    16p13.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (8621698..8667274)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (8654289..8706324)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8715555..8743511)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:8566588-8567787 Neighboring gene transmembrane protein 114 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:8602648-8603380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8733020-8733520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8767471-8767972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8767973-8768472 Neighboring gene RNA, 7SL, cytoplasmic 743, pseudogene Neighboring gene 4-aminobutyrate aminotransferase Neighboring gene RNA, U7 small nuclear 63 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin. Cloutier P, et al. J Proteomics, 2014 Apr 4. PMID 24140279
    2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013. PMID 23349634, Free PMC Article
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL22 trimethylates Lys-135 in Kin17
      Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2654, FLJ12433

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methyltransferase-like protein 22
    Names
    LP8272
    methyltransferase like 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024109.4 → NP_077014.4  methyltransferase-like protein 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
      Source sequence(s)
      AC007224, AC138420
      Consensus CDS
      CCDS10533.2
      UniProtKB/Swiss-Prot
      B2RD29, D3DUF2, Q6XYB4, Q9BUU2, Q9HA03
      UniProtKB/TrEMBL
      H3BTF5
      Related
      ENSP00000371345.3, ENST00000381920.8
      Conserved Domains (1) summary
      cl17173
      Location:164 → 337
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_134608.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant (2) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC007224, AC138420

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      8621698..8667274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023660.2 → XP_016879149.1  methyltransferase-like protein 22 isoform X2

    2. XM_047434610.1 → XP_047290566.1  methyltransferase-like protein 22 isoform X1

    3. XM_017023659.3 → XP_016879148.1  methyltransferase-like protein 22 isoform X2

    4. XM_047434613.1 → XP_047290569.1  methyltransferase-like protein 22 isoform X4

      UniProtKB/Swiss-Prot
      B2RD29, D3DUF2, Q6XYB4, Q9BUU2, Q9HA03
      UniProtKB/TrEMBL
      H3BTF5

    5. XM_047434612.1 → XP_047290568.1  methyltransferase-like protein 22 isoform X4

      UniProtKB/Swiss-Prot
      B2RD29, D3DUF2, Q6XYB4, Q9BUU2, Q9HA03
      UniProtKB/TrEMBL
      H3BTF5

    6. XM_047434614.1 → XP_047290570.1  methyltransferase-like protein 22 isoform X6

      UniProtKB/TrEMBL
      H3BTF5

    7. XM_005255571.4 → XP_005255628.1  methyltransferase-like protein 22 isoform X6

      UniProtKB/TrEMBL
      H3BTF5
      Conserved Domains (1) summary
      cl17173
      Location:164 → 338
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    8. XM_047434611.1 → XP_047290567.1  methyltransferase-like protein 22 isoform X3

    9. XM_005255570.5 → XP_005255627.1  methyltransferase-like protein 22 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:164 → 337
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    10. XM_024450439.2 → XP_024306207.1  methyltransferase-like protein 22 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:164 → 320
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    11. XM_047434615.1 → XP_047290571.1  methyltransferase-like protein 22 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      8654289..8706324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313894.1 → XP_054169869.1  methyltransferase-like protein 22 isoform X8

    2. XM_054313897.1 → XP_054169872.1  methyltransferase-like protein 22 isoform X2

    3. XM_054313895.1 → XP_054169870.1  methyltransferase-like protein 22 isoform X1

    4. XM_054313896.1 → XP_054169871.1  methyltransferase-like protein 22 isoform X2

    5. XM_054313901.1 → XP_054169876.1  methyltransferase-like protein 22 isoform X4

      UniProtKB/TrEMBL
      H3BTF5

    6. XM_054313900.1 → XP_054169875.1  methyltransferase-like protein 22 isoform X4

      UniProtKB/TrEMBL
      H3BTF5

    7. XM_054313904.1 → XP_054169879.1  methyltransferase-like protein 22 isoform X6

      UniProtKB/TrEMBL
      H3BTF5

    8. XM_054313903.1 → XP_054169878.1  methyltransferase-like protein 22 isoform X6

      UniProtKB/TrEMBL
      H3BTF5

    9. XM_054313899.1 → XP_054169874.1  methyltransferase-like protein 22 isoform X9

    10. XM_054313898.1 → XP_054169873.1  methyltransferase-like protein 22 isoform X9

    11. XM_054313902.1 → XP_054169877.1  methyltransferase-like protein 22 isoform X5

    12. XM_054313905.1 → XP_054169880.1  methyltransferase-like protein 22 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BUU2.2 GenPept UniProtKB/Swiss-Prot:Q9BUU2

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