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    Fbxo21 F-box protein 21 [ Mus musculus (house mouse) ]

    Gene ID: 231670, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fbxo21provided by MGI
    Official Full Name
    F-box protein 21provided by MGI
    Primary source
    MGI:MGI:1924223
    See related
    Ensembl:ENSMUSG00000032898 AllianceGenome:MGI:1924223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810425J22Rik
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; hematopoietic stem cell differentiation; and hematopoietic stem cell homeostasis. Is expressed in nervous system and neural retina. Orthologous to human FBXO21 (F-box protein 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 54.7), whole brain E14.5 (RPKM 49.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo21 in Genome Data Viewer
    Location:
    5 F; 5 57.73 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118114835..118148263)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117976770..118010198)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Nos1 exon 2 regulatory region Neighboring gene predicted gene, 30360 Neighboring gene STARR-seq mESC enhancer starr_14186 Neighboring gene STARR-seq mESC enhancer starr_14187 Neighboring gene nitric oxide synthase 1, neuronal Neighboring gene predicted gene, 26995 Neighboring gene STARR-positive B cell enhancer ABC_E4781 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:118486912-118487121 Neighboring gene tescalcin Neighboring gene predicted gene 9754 Neighboring gene F-box and WD-40 domain protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis. Wittorf KJ, et al. Exp Hematol, 2022 Oct. PMID 35987460
    2. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. Yu Z, et al. Elife, 2016 Apr 11. PMID 27063938, Free PMC Article
    3. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Del Prete D, et al. J Biol Chem, 2016 Aug 12. PMID 27325702, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    5. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis.
      Title: Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis.
    2. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
      Title: Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0875, MGC28066

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to 5-fluorouracil IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346588.1 → NP_001333517.1  F-box only protein 21 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK048131, AK049723, BE954194, BP754360, BY478760
      Consensus CDS
      CCDS84947.1
      UniProtKB/TrEMBL
      A0A0J9YU92
      Related
      ENSMUSP00000035506.8, ENSMUST00000035579.10

    2. NM_145564.4 → NP_663539.1  F-box only protein 21 isoform 1

      See identical proteins and their annotated locations for NP_663539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK049723, BP754360
      Consensus CDS
      CCDS19607.1
      UniProtKB/Swiss-Prot
      Q8BHA5, Q8CHC6, Q8VDH1
      UniProtKB/TrEMBL
      A0A0J9YU92
      Related
      ENSMUSP00000143873.2, ENSMUST00000202447.4
      Conserved Domains (3) summary
      TIGR02097
      Location:500 → 597
      yccV; hemimethylated DNA binding domain
      pfam12937
      Location:30 → 78
      F-box-like; F-box-like
      pfam13369
      Location:258 → 388
      Transglut_core2; Transglutaminase-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      118114835..118148263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDH1.1 GenPept UniProtKB/Swiss-Prot:Q8VDH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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