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    Itpripl1 inositol 1,4,5-triphosphate receptor interacting protein-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 73338, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Itpripl1provided by MGI
    Official Full Name
    inositol 1,4,5-triphosphate receptor interacting protein-like 1provided by MGI
    Primary source
    MGI:MGI:1920588
    See related
    Ensembl:ENSMUSG00000074825 AllianceGenome:MGI:1920588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700041B20Rik
    Summary
    Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human ITPRIPL1 (ITPRIP like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.7), mammary gland adult (RPKM 5.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itpripl1 in Genome Data Viewer
    Location:
    2 F1; 2 61.79 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126980689..126985377, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127138769..127143457, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene non-SMC condensin I complex, subunit H Neighboring gene STARR-positive B cell enhancer ABC_E3400 Neighboring gene STARR-seq mESC enhancer starr_05620 Neighboring gene predicted gene, 35347 Neighboring gene STARR-positive B cell enhancer ABC_E8792 Neighboring gene STARR-seq mESC enhancer starr_05621 Neighboring gene RIKEN cDNA 1810024B03 gene Neighboring gene STARR-positive B cell enhancer ABC_E3401 Neighboring gene small nuclear ribonucleoprotein 200 (U5)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Development of a monoclonal antibody to ITPRIPL1 for immunohistochemical diagnosis of non-small cell lung cancers: accuracy and correlation with CD8(+) T cell infiltration. Deng S, et al. Front Cell Dev Biol, 2023. PMID 38188019, Free PMC Article
    2. ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion. Deng S, et al. Cell, 2024 Apr 25. PMID 38614099
    3. Comparative sequence analysis of a single-gene conserved segment in mouse and human. Thomas JW, et al. Mamm Genome, 2003 Oct. PMID 14694903
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163527.1 → NP_001156999.1  inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001156999.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL928590
      Consensus CDS
      CCDS50701.1
      UniProtKB/Swiss-Prot
      A1L3P2, A2ASA8, B7ZCY2
      Related
      ENSMUSP00000106016.2, ENSMUST00000110386.2
      Conserved Domains (1) summary
      pfam03281
      Location:287 → 514
      Mab-21; Mab-21 protein

    2. NM_001163528.1 → NP_001157000.1  inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001157000.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL928590
      Consensus CDS
      CCDS50701.1
      UniProtKB/Swiss-Prot
      A1L3P2, A2ASA8, B7ZCY2
      Related
      ENSMUSP00000122289.2, ENSMUST00000154021.2
      Conserved Domains (1) summary
      pfam03281
      Location:287 → 514
      Mab-21; Mab-21 protein

    3. NM_001355634.1 → NP_001342563.1  inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal segment compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK028913, AL928590
      Consensus CDS
      CCDS89550.1
      UniProtKB/TrEMBL
      A2ASB0
      Related
      ENSMUSP00000118487.2, ENSMUST00000132773.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      126980689..126985377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252117.2 → XP_030107977.1  inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ASA8.2 GenPept UniProtKB/Swiss-Prot:A2ASA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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