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    Tspan18 tetraspanin 18 [ Mus musculus (house mouse) ]

    Gene ID: 241556, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tspan18provided by MGI
    Official Full Name
    tetraspanin 18provided by MGI
    Primary source
    MGI:MGI:1917186
    See related
    Ensembl:ENSMUSG00000027217 AllianceGenome:MGI:1917186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6720430O15; 2610042G18Rik
    Summary
    Predicted to enable transmembrane transporter binding activity. Acts upstream of or within several processes, including calcium-ion regulated exocytosis; hemostasis; and inflammatory response. Predicted to be located in cell periphery. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human TSPAN18 (tetraspanin 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 39.7), adrenal adult (RPKM 19.1) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspan18 in Genome Data Viewer
    Location:
    2 E1; 2 51.37 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93032105..93164898, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (93201760..93334551, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93032831-93033064 Neighboring gene predicted gene, 32683 Neighboring gene transformation related protein 53 inducible protein 11 Neighboring gene predicted gene, 32824 Neighboring gene predicted gene, 39882 Neighboring gene VISTA enhancer mm1603 Neighboring gene predicted gene, 39881 Neighboring gene predicted gene, 32745 Neighboring gene predicted gene 13807

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tspan18 is a novel regulator of thrombo-inflammation. Gavin RL, et al. Med Microbiol Immunol, 2020 Aug. PMID 32447449, Free PMC Article
    2. Tspan18 is a novel regulator of the Ca(2+) channel Orai1 and von Willebrand factor release in endothelial cells. Noy PJ, et al. Haematologica, 2019 Sep. PMID 30573509, Free PMC Article
    3. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
    4. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
    5. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tspan18 is a novel regulator of thrombo-inflammation.
      Title: Tspan18 is a novel regulator of thrombo-inflammation.
    2. The findings identify Tspan18 as a novel regulator of endothelial cell Orai1/Ca2+ signaling and von Willebrand factor release in response to inflammatory stimuli.
      Title: Tspan18 is a novel regulator of the Ca(2+) channel Orai1 and von Willebrand factor release in endothelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-ion regulated exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-18
    Names
    tspan-18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183180.2 → NP_899003.1  tetraspanin-18

      See identical proteins and their annotated locations for NP_899003.1

      Status: VALIDATED

      Source sequence(s)
      AL691472, BB659903, BC052169
      Consensus CDS
      CCDS38182.1
      UniProtKB/Swiss-Prot
      Q80WR1
      Related
      ENSMUSP00000106896.3, ENSMUST00000111265.9
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      93032105..93164898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499475.5 → XP_006499538.1  tetraspanin-18 isoform X1

      See identical proteins and their annotated locations for XP_006499538.1

      UniProtKB/Swiss-Prot
      Q80WR1
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family

    2. XM_006499476.5 → XP_006499539.1  tetraspanin-18 isoform X1

      See identical proteins and their annotated locations for XP_006499539.1

      UniProtKB/Swiss-Prot
      Q80WR1
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family

    3. XM_006499474.5 → XP_006499537.1  tetraspanin-18 isoform X1

      See identical proteins and their annotated locations for XP_006499537.1

      UniProtKB/Swiss-Prot
      Q80WR1
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family

    4. XM_011239525.3 → XP_011237827.1  tetraspanin-18 isoform X1

      See identical proteins and their annotated locations for XP_011237827.1

      UniProtKB/Swiss-Prot
      Q80WR1
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family

    5. XM_006499477.5 → XP_006499540.1  tetraspanin-18 isoform X1

      See identical proteins and their annotated locations for XP_006499540.1

      UniProtKB/Swiss-Prot
      Q80WR1
      Related
      ENSMUSP00000028646.3, ENSMUST00000028646.4
      Conserved Domains (2) summary
      cd03156
      Location:105 → 218
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 243
      Tetraspannin; Tetraspanin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WR1.1 GenPept UniProtKB/Swiss-Prot:Q80WR1

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