Bnip3l BCL2/adenovirus E1B interacting protein 3-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bnip3lprovided by MGI
Official Full Name: BCL2/adenovirus E1B interacting protein 3-likeprovided by MGI
Primary source: MGI:MGI:1332659
See related: Ensembl:ENSMUSG00000022051 AllianceGenome:MGI:1332659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nix; Nip3L; D14Ertd719e
Summary: Enables identical protein binding activity. Involved in regulation of mitophagy and regulation of protein targeting to mitochondrion. Acts upstream of or within positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human BNIP3L (BCL2 interacting protein 3 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 35.8), liver E14.5 (RPKM 29.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.6 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (67222688..67246580, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (66985238..67008877, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Title: A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
BNIP3L/NIX regulates both mitophagy and pexophagy.
Title: BNIP3L/NIX regulates both mitophagy and pexophagy.
NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation.
Title: NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation.
Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal Inflammation.
Title: Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal Inflammation.
BCL2 Interacting Protein 3-like/NIX-mediated Mitophagy Plays an Important Role in the Process of Age-related Hearing Loss.
Title: BCL2 Interacting Protein 3-like/NIX-mediated Mitophagy Plays an Important Role in the Process of Age-related Hearing Loss.
MiR-133a alleviates renal injury caused by sepsis by targeting BNIP3L.
Title: MiR-133a alleviates renal injury caused by sepsis by targeting BNIP3L.
BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects.
Title: BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects.
NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells.
Title: NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells.
our findings reveal a novel mechanistic link between Nix-mediated mitophagy, platelet life span, and platelet physiopathology. Our work suggests that targeting platelet mitophagy Nix might provide new antithrombotic strategies
Title: Nix-mediated mitophagy regulates platelet activation and life span.
BNIP3L- and FUNDC1-mediated mitophagy is a critical regulator of mitochondrial network formation during differentiation, as well as the consequences of accumulating mtDNA mutations.
Title: BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136246 (e-PCR)
- UniSTS:210240

Bnip3l (e-PCR), detects polymorphism
- UniSTS:506755

RH127267 (e-PCR)
- UniSTS:209807

D14Ertd719e (e-PCR), detects polymorphism
- UniSTS:167145

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	IEA Inferred from Electronic Annotation more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial outer membrane permeabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of programmed cell death	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein targeting to mitochondrion	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Names: BCL2/adenovirus E1B 19 kDa-interacting protein 3-like; BCL2/adenovirus E1B 19kDa-interacting protein 3-like; NIP3-like protein X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001422131.1 → NP_001409060.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

Status: VALIDATED

Source sequence(s)

AC165148

UniProtKB/TrEMBL

Q3TEW0
NM_001422132.1 → NP_001409061.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

Status: VALIDATED

Source sequence(s)

AC165148

UniProtKB/TrEMBL

Q3TEW0
NM_001422133.1 → NP_001409062.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

Status: VALIDATED

Source sequence(s)

AC165148

UniProtKB/TrEMBL

Q3TEW0
NM_001422134.1 → NP_001409063.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

Status: VALIDATED

Source sequence(s)

AC165148

UniProtKB/TrEMBL

Q3TEW0
NM_009761.4 → NP_033891.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

See identical proteins and their annotated locations for NP_033891.1

Status: VALIDATED

Source sequence(s)

AC165148

Consensus CDS

CCDS27227.1

UniProtKB/Swiss-Prot

Q545J6, Q9Z2F7

UniProtKB/TrEMBL

Q3TEW0

Related

ENSMUSP00000022634.9, ENSMUST00000022634.9

Conserved Domains (1) summary

pfam06553
Location:22 → 217

BNIP3; BNIP3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

67222688..67246580 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158414.1 → XP_036014307.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1

Conserved Domains (1) summary

pfam06553
Location:101 → 277

BNIP3