Srgn serglycin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srgnprovided by MGI
Official Full Name: serglycinprovided by MGI
Primary source: MGI:MGI:97756
See related: Ensembl:ENSMUSG00000020077 AllianceGenome:MGI:97756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prg; Sgc; Prg1
Summary: Predicted to enable collagen binding activity. Involved in negative regulation of cytokine production; protein localization to secretory granule; and protein processing. Located in mast cell granule. Is expressed in several structures, including autopod; central nervous system; liver; lower jaw; and thymus primordium. Orthologous to human SRGN (serglycin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 7.7), spleen adult (RPKM 6.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.42 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62329612..62363224, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62493833..62527445, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury.
Title: SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury.
Serglycin Is Involved in Adipose Tissue Inflammation in Obesity.
Title: Serglycin Is Involved in Adipose Tissue Inflammation in Obesity.
Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis.
Title: Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis.
serglycin produced in lipopolysaccharide-induced inflammation in normal mouse chondrocytes is able to modulate inflammation by interacting with CD44 receptor, suggesting a possible key role in the cartilage inflammation.
Title: Serglycin is involved in inflammatory response in articular mouse chondrocytes.
Findings indicate that PRG-1 deficiency led to over-excitability caused by an altered LPA/LPA2-R signaling inducing a behavioral phenotype typically observed in animal models for psychiatric disorders.
Title: Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
this study shows that the serglycin-deficient mice are more susceptible to Trichinella spiralis infection and display an unbalanced immune response
Title: Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice.
Data suggest that serglycin proteoglycans play a role in extravasation as well as colonization and growth of metastatic cells.
Title: Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma.
serglycin deficient mice exhibited elevated concentrations of serum LDL after feeding high-fat diet for 20 weeks.
Title: Serglycin protects against high fat diet-induced increase in serum LDL in mice.
serglycin plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin and granzyme B, whereas granzyme A is unaffected
Title: Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.
Wild-type mast cells efficiently degraded exogenous or endogenously produced IL-13 upon degranulation,whereas serglycin -/- mast cells completely lacked this ability.
Title: Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Srgn (e-PCR), detects polymorphism
- UniSTS:495905

Srgn (e-PCR), detects polymorphism
- UniSTS:495906

Prg (e-PCR), detects polymorphism
- UniSTS:144257

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell secretory granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in granzyme-mediated programmed cell death signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of granzyme B location in T cell secretory granule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protease location in mast cell secretory granule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mast cell secretory granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in secretory granule organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytolytic granule	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in mast cell granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in zymogen granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serglycin

Names: gp600; mastocytoma proteoglycan core protein; proteoglycan 1, secretory granule; proteoglycan, secretory granule; secretory granule proteoglycan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358965.2 → NP_001345894.1 serglycin isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR, compared to variant 1. Variants 1-3 all encode the same isoform (b).

Source sequence(s)

AC126428

Consensus CDS

CCDS23889.1

UniProtKB/Swiss-Prot

P13609, Q3TZD4, Q8C2U2

Related

ENSMUSP00000125622.2, ENSMUST00000160987.8

Conserved Domains (1) summary

pfam04360
Location:3 → 148

Serglycin
NM_001428754.1 → NP_001415683.1 serglycin isoform b precursor

Status: VALIDATED

Source sequence(s)

AC126428

UniProtKB/Swiss-Prot

P13609, Q3TZD4, Q8C2U2
NM_001428755.1 → NP_001415684.1 serglycin isoform a

Status: VALIDATED

Source sequence(s)

AC126428
NM_011157.4 → NP_035287.1 serglycin isoform b precursor

See identical proteins and their annotated locations for NP_035287.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant but shortest transcript and encodes isoform b. It has a transcriptional start site that is internal relative to that of the other variants. Variants 1-3 all encode the same isoform (b).

Source sequence(s)

AC126428

Consensus CDS

CCDS23889.1

UniProtKB/Swiss-Prot

P13609, Q3TZD4, Q8C2U2

Related

ENSMUSP00000020271.7, ENSMUST00000020271.13

Conserved Domains (1) summary

pfam04360
Location:3 → 148

Serglycin