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    Naxe NAD(P)HX epimerase [ Mus musculus (house mouse) ]

    Gene ID: 246703, updated on 9-Dec-2024

    Summary

    Official Symbol
    Naxeprovided by MGI
    Official Full Name
    NAD(P)HX epimeraseprovided by MGI
    Primary source
    MGI:MGI:2180167
    See related
    Ensembl:ENSMUSG00000028070 AllianceGenome:MGI:2180167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIBP; AI-BP; ESTM37; Apoa1bp; Apoa1ip
    Summary
    Enables identical protein binding activity. Predicted to be involved in several processes, including membrane raft distribution; negative regulation of angiogenesis; and regulation of cholesterol efflux. Located in several cellular components, including cell body; extracellular space; and mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and skeletal muscle tissue. Orthologous to human NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 55.9), adrenal adult (RPKM 49.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Naxe in Genome Data Viewer
    Location:
    3 F1; 3 38.78 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87963827..87965851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88056520..88058542, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19439 Neighboring gene STARR-positive B cell enhancer ABC_E10191 Neighboring gene G patch domain containing 4 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene STARR-positive B cell enhancer ABC_E10192 Neighboring gene IQ motif containing GTPase activating protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD(P)HX epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD(P)HX epimerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane raft distribution ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane raft distribution ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in metabolite repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nicotinamide nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nicotinamide nucleotide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    NAD(P)H-hydrate epimerase
    Names
    apoA-I binding protein
    apolipoprotein A-I binding protein
    apolipoprotein A-I interacting protein
    NP_001396696.1
    NP_001396697.1
    NP_001396699.1
    NP_001396700.1
    NP_001396702.1
    NP_001396703.1
    NP_001396704.1
    NP_001396705.1
    NP_001396706.1
    NP_001396707.1
    NP_001396708.1
    NP_001396709.1
    NP_659146.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409767.1NP_001396696.1  NAD(P)H-hydrate epimerase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC137525
    2. NM_001409768.1NP_001396697.1  NAD(P)H-hydrate epimerase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC137525
    3. NM_001409770.1NP_001396699.1  NAD(P)H-hydrate epimerase isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC137525
    4. NM_001409771.1NP_001396700.1  NAD(P)H-hydrate epimerase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC137525
    5. NM_001409773.1NP_001396702.1  NAD(P)H-hydrate epimerase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC137525
    6. NM_001409774.1NP_001396703.1  NAD(P)H-hydrate epimerase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC137525
    7. NM_001409775.1NP_001396704.1  NAD(P)H-hydrate epimerase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC137525
    8. NM_001409776.1NP_001396705.1  NAD(P)H-hydrate epimerase isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC137525
    9. NM_001409777.1NP_001396706.1  NAD(P)H-hydrate epimerase isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC137525
    10. NM_001409778.1NP_001396707.1  NAD(P)H-hydrate epimerase isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC137525
    11. NM_001409779.1NP_001396708.1  NAD(P)H-hydrate epimerase isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC137525
    12. NM_001409780.1NP_001396709.1  NAD(P)H-hydrate epimerase isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC137525
    13. NM_144897.4NP_659146.1  NAD(P)H-hydrate epimerase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC137525
      Consensus CDS
      CCDS17464.1
      UniProtKB/Swiss-Prot
      Q8K4Z3
      Related
      ENSMUSP00000029708.7, ENSMUST00000029708.8
      Conserved Domains (1) summary
      cl00318
      Location:46281
      YjeF_N; YjeF-related protein N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87963827..87965851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004941327.1 RNA Sequence