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    Mef2d myocyte enhancer factor 2D [ Mus musculus (house mouse) ]

    Gene ID: 17261, updated on 3-Dec-2024

    Summary

    Official Symbol
    Mef2dprovided by MGI
    Official Full Name
    myocyte enhancer factor 2Dprovided by MGI
    Primary source
    MGI:MGI:99533
    See related
    Ensembl:ENSMUSG00000001419 AllianceGenome:MGI:99533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein dimerization activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including osteoblast differentiation; skeletal muscle cell differentiation; and skeletal system development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; female reproductive system; and urinary system. Orthologous to human MEF2D (myocyte enhancer factor 2D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 72.5), ovary adult (RPKM 42.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mef2d in Genome Data Viewer
    Location:
    3 F1; 3 38.78 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88049248..88079398)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88141941..88172091)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10192 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene IQ motif containing GTPase activating protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E10193 Neighboring gene STARR-positive B cell enhancer ABC_E1621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87942601-87942788 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87945923-87946106 Neighboring gene STARR-positive B cell enhancer ABC_E2075 Neighboring gene RIKEN cDNA 1700113A16 gene Neighboring gene expressed sequence AI849053 Neighboring gene expressed sequence AW047730

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC31718

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adult heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within chondrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within endochondral ossification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myocyte-specific enhancer factor 2D

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310587.2NP_001297516.1  myocyte-specific enhancer factor 2D isoform 1

      See identical proteins and their annotated locations for NP_001297516.1

      Status: VALIDATED

      Source sequence(s)
      AC137525
      Consensus CDS
      CCDS79939.1
      UniProtKB/Swiss-Prot
      E9QKS9, Q63943, Q63944
      UniProtKB/TrEMBL
      Q3URR2
      Related
      ENSMUSP00000103184.3, ENSMUST00000107559.3
      Conserved Domains (2) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    2. NM_001310593.2NP_001297522.1  myocyte-specific enhancer factor 2D isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC137525
      Consensus CDS
      CCDS79940.1
      UniProtKB/TrEMBL
      E9QKT0, Q3URR2
      Related
      ENSMUSP00000103183.3, ENSMUST00000107558.9
      Conserved Domains (2) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:96150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    3. NM_001410077.1NP_001397006.1  myocyte-specific enhancer factor 2D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/Swiss-Prot
      E9QKS9, Q63943, Q63944
      UniProtKB/TrEMBL
      Q3URR2
    4. NM_001410078.1NP_001397007.1  myocyte-specific enhancer factor 2D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/Swiss-Prot
      E9QKS9, Q63943, Q63944
      UniProtKB/TrEMBL
      Q3URR2
    5. NM_001410079.1NP_001397008.1  myocyte-specific enhancer factor 2D isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    6. NM_001410080.1NP_001397009.1  myocyte-specific enhancer factor 2D isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    7. NM_001410081.1NP_001397010.1  myocyte-specific enhancer factor 2D isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    8. NM_001410082.1NP_001397011.1  myocyte-specific enhancer factor 2D isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    9. NM_001410083.1NP_001397012.1  myocyte-specific enhancer factor 2D isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    10. NM_001410084.1NP_001397013.1  myocyte-specific enhancer factor 2D isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    11. NM_001410085.1NP_001397014.1  myocyte-specific enhancer factor 2D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2, Q921S6
    12. NM_001410086.1NP_001397015.1  myocyte-specific enhancer factor 2D isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      E9Q5E0, Q3URR2
      Related
      ENSMUSP00000113638.2, ENSMUST00000119251.8
    13. NM_001410087.1NP_001397016.1  myocyte-specific enhancer factor 2D isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      E9Q5E0, Q3URR2
    14. NM_001410088.1NP_001397017.1  myocyte-specific enhancer factor 2D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    15. NM_001410089.1NP_001397018.1  myocyte-specific enhancer factor 2D isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    16. NM_001410090.1NP_001397019.1  myocyte-specific enhancer factor 2D isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    17. NM_001410091.1NP_001397020.1  myocyte-specific enhancer factor 2D isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    18. NM_001410092.1NP_001397021.1  myocyte-specific enhancer factor 2D isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    19. NM_001410093.1NP_001397022.1  myocyte-specific enhancer factor 2D isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC137525
      UniProtKB/TrEMBL
      Q3URR2
    20. NM_001410094.1NP_001397023.1  myocyte-specific enhancer factor 2D isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC137525
    21. NM_001410095.1NP_001397024.1  myocyte-specific enhancer factor 2D isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC137525
    22. NM_001410096.1NP_001397025.1  myocyte-specific enhancer factor 2D isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC137525
    23. NM_001410097.1NP_001397026.1  myocyte-specific enhancer factor 2D isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC137525
    24. NM_001410098.1NP_001397027.1  myocyte-specific enhancer factor 2D isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC137525
    25. NM_001410099.1NP_001397028.1  myocyte-specific enhancer factor 2D isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC137525
    26. NM_001410100.1NP_001397029.1  myocyte-specific enhancer factor 2D isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC137525
    27. NM_001410101.1NP_001397030.1  myocyte-specific enhancer factor 2D isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC137525
    28. NM_001410102.1NP_001397031.1  myocyte-specific enhancer factor 2D isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC137525
    29. NM_001410103.1NP_001397032.1  myocyte-specific enhancer factor 2D isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC137525
    30. NM_001410104.1NP_001397033.1  myocyte-specific enhancer factor 2D isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC137525
    31. NM_001410105.1NP_001397034.1  myocyte-specific enhancer factor 2D isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC137525
    32. NM_133665.5NP_598426.1  myocyte-specific enhancer factor 2D isoform 2

      See identical proteins and their annotated locations for NP_598426.1

      Status: VALIDATED

      Source sequence(s)
      AC137525
      Consensus CDS
      CCDS38479.1
      UniProtKB/TrEMBL
      Q3URR2, Q921S6
      Related
      ENSMUSP00000001455.7, ENSMUST00000001455.13
      Conserved Domains (3) summary
      COG5068
      Location:1346
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RNA

    1. NR_176939.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137525
    2. NR_176940.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137525
    3. NR_176941.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137525

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88049248..88079398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319472.2XP_017174961.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      E9QKS9, Q63943, Q63944
      UniProtKB/TrEMBL
      Q3URR2
      Conserved Domains (2) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    2. XM_011240034.3XP_011238336.1  myocyte-specific enhancer factor 2D isoform X7

      Conserved Domains (3) summary
      PHA03247
      Location:126257
      PHA03247; large tegument protein UL36; Provisional
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    3. XM_011240032.3XP_011238334.1  myocyte-specific enhancer factor 2D isoform X3

      See identical proteins and their annotated locations for XP_011238334.1

      UniProtKB/TrEMBL
      Q3URR2, Q921S6
      Conserved Domains (3) summary
      COG5068
      Location:1346
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    4. XM_030252450.2XP_030108310.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      E9QKS9, Q63943, Q63944
      UniProtKB/TrEMBL
      Q3URR2
      Conserved Domains (2) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    5. XM_006501090.4XP_006501153.1  myocyte-specific enhancer factor 2D isoform X2

      UniProtKB/TrEMBL
      Q3URR2
      Conserved Domains (2) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:96150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    6. XM_017319473.2XP_017174962.1  myocyte-specific enhancer factor 2D isoform X4

      UniProtKB/TrEMBL
      E9QKT0, Q3URR2
      Conserved Domains (2) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:96150
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    7. XM_011240033.3XP_011238335.1  myocyte-specific enhancer factor 2D isoform X5

      UniProtKB/TrEMBL
      Q3URR2
      Conserved Domains (2) summary
      COG5068
      Location:1156
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...