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    Iqgap3 IQ motif containing GTPase activating protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 404710, updated on 9-Dec-2024

    Summary

    Official Symbol
    Iqgap3provided by MGI
    Official Full Name
    IQ motif containing GTPase activating protein 3provided by MGI
    Primary source
    MGI:MGI:3028642
    See related
    Ensembl:ENSMUSG00000028068 AllianceGenome:MGI:3028642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030034H08
    Summary
    Enables small GTPase binding activity. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; intracellular signaling cassette; and regulation of gene expression. Located in cell-cell junction; cytoplasm; and lateral plasma membrane. Is expressed in stomach glandular region gastric gland. Orthologous to human IQGAP3 (IQ motif containing GTPase activating protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 10.4), CNS E11.5 (RPKM 6.6) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Iqgap3 in Genome Data Viewer
    Location:
    3 F1; 3 38.78 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87989309..88028355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88082002..88121048)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene NAD(P)HX epimerase Neighboring gene STARR-positive B cell enhancer ABC_E10192 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene STARR-positive B cell enhancer ABC_E10193 Neighboring gene STARR-positive B cell enhancer ABC_E1621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87942601-87942788 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87945923-87946106 Neighboring gene STARR-positive B cell enhancer ABC_E2075 Neighboring gene myocyte enhancer factor 2D Neighboring gene RIKEN cDNA 1700113A16 gene Neighboring gene expressed sequence AI849053

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC32192

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin VI light chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras GTPase-activating-like protein IQGAP3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033484.1NP_001028656.1  ras GTPase-activating-like protein IQGAP3

      See identical proteins and their annotated locations for NP_001028656.1

      Status: VALIDATED

      Source sequence(s)
      BC068159, CA750580, CX200367
      Consensus CDS
      CCDS38478.1
      UniProtKB/TrEMBL
      B9EKT6, F8VQ29
      Related
      ENSMUSP00000071715.6, ENSMUST00000071812.11
      Conserved Domains (5) summary
      smart00015
      Location:764782
      IQ; Calmodulin-binding motif
      smart00323
      Location:9771328
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:35147
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam03836
      Location:14341555
      RasGAP_C; RasGAP C-terminus
      cl02569
      Location:9881337
      RasGAP; Ras GTPase Activating Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87989309..88028355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501643.3XP_006501706.1  ras GTPase-activating-like protein IQGAP3 isoform X1

      UniProtKB/TrEMBL
      B9EKT6
      Conserved Domains (4) summary
      smart00015
      Location:501519
      IQ; Calmodulin-binding motif
      COG5261
      Location:5991369
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cd00201
      Location:408433
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl02569
      Location:7251074
      RasGAP; Ras GTPase Activating Domain