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    Mettl24 methyltransferase like 24 [ Mus musculus (house mouse) ]

    Gene ID: 327747, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mettl24provided by MGI
    Official Full Name
    methyltransferase like 24provided by MGI
    Primary source
    MGI:MGI:3045338
    See related
    Ensembl:ENSMUSG00000045555 AllianceGenome:MGI:3045338
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030224M15Rik
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in extracellular region. Orthologous to human METTL24 (methyltransferase like 24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 4.0), lung adult (RPKM 3.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl24 in Genome Data Viewer
    Location:
    10 B1; 10 22.02 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40558447..40687080)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40682445..40812733)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26428 Neighboring gene solute carrier family 22 (organic cation transporter), member 16 Neighboring gene D-aspartate oxidase Neighboring gene STARR-seq mESC enhancer starr_26430 Neighboring gene STARR-seq mESC enhancer starr_26431 Neighboring gene STARR-seq mESC enhancer starr_26432 Neighboring gene STARR-seq mESC enhancer starr_26433 Neighboring gene STARR-seq mESC enhancer starr_26435 Neighboring gene cell division cycle 40 Neighboring gene STARR-positive B cell enhancer ABC_E2320 Neighboring gene WASP family, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable methyltransferase-like protein 24
    Names
    UPF0624 protein C6orf186 homolog
    methyltransferase-like protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177793.3 → NP_808461.1  probable methyltransferase-like protein 24 precursor

      See identical proteins and their annotated locations for NP_808461.1

      Status: PROVISIONAL

      Source sequence(s)
      AK033488
      Consensus CDS
      CCDS23799.1
      UniProtKB/Swiss-Prot
      Q8CCB5
      Related
      ENSMUSP00000049997.4, ENSMUST00000058747.4
      Conserved Domains (1) summary
      cl17173
      Location:178 → 295
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      40558447..40687080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245130.2 → XP_030100990.1  probable methyltransferase-like protein 24 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:1 → 101
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_030245132.2 → XP_030100992.1  probable methyltransferase-like protein 24 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:1 → 101
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_006512765.5 → XP_006512828.1  probable methyltransferase-like protein 24 isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:184 → 309
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_006512767.5 → XP_006512830.1  probable methyltransferase-like protein 24 isoform X3

    5. XM_006512768.5 → XP_006512831.1  probable methyltransferase-like protein 24 isoform X4

    6. XM_006512766.5 → XP_006512829.1  probable methyltransferase-like protein 24 isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:137 → 262
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. XM_036155823.1 → XP_036011716.1  probable methyltransferase-like protein 24 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:1 → 101
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    8. XM_030245131.2 → XP_030100991.1  probable methyltransferase-like protein 24 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:1 → 101
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CCB5.1 GenPept UniProtKB/Swiss-Prot:Q8CCB5

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