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    Tram1 translocating chain-associating membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 72265, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tram1provided by MGI
    Official Full Name
    translocating chain-associating membrane protein 1provided by MGI
    Primary source
    MGI:MGI:1919515
    See related
    Ensembl:ENSMUSG00000025935 AllianceGenome:MGI:1919515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRAMP; 1810049E02Rik
    Summary
    This gene encodes a multi-pass transmembrane protein of the endoplasmic reticulum (ER). It is involved in the process of cotranslational translocation of secretory proteins into the ER. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in placenta adult (RPKM 47.6), testis adult (RPKM 32.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tram1 in Genome Data Viewer
    Location:
    1 A3; 1 4.18 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13634917..13660134, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13564693..13589910, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39595 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene STARR-seq mESC enhancer starr_00273 Neighboring gene predicted gene, 39600 Neighboring gene STARR-seq mESC enhancer starr_00275 Neighboring gene STARR-seq mESC enhancer starr_00276 Neighboring gene STARR-seq mESC enhancer starr_00277 Neighboring gene STARR-seq mESC enhancer starr_00278 Neighboring gene STARR-seq mESC enhancer starr_00279 Neighboring gene lactamase, beta 2 Neighboring gene STARR-seq mESC enhancer starr_00283 Neighboring gene STARR-seq mESC enhancer starr_00284 Neighboring gene X-linked Kx blood group related 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC1174

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cotranslational protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cotranslational protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to unfolded protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    translocating chain-associated membrane protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028173.5NP_082449.1  translocating chain-associated membrane protein 1

      See identical proteins and their annotated locations for NP_082449.1

      Status: REVIEWED

      Source sequence(s)
      AC157769
      Consensus CDS
      CCDS14822.1
      UniProtKB/Swiss-Prot
      Q91V04
      UniProtKB/TrEMBL
      Q3UAT2, Q3UQ93, Q4FK14
      Related
      ENSMUSP00000027068.5, ENSMUST00000027068.11
      Conserved Domains (2) summary
      smart00724
      Location:117326
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:47115
      TRAM1; TRAM1-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      13634917..13660134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)