SIN3B SIN3 transcription regulator family member B [Homo sapiens (human)] - Gene

Summary

Official Symbol: SIN3Bprovided by HGNC
Official Full Name: SIN3 transcription regulator family member Bprovided by HGNC
Primary source: HGNC:HGNC:19354
See related: Ensembl:ENSG00000127511 MIM:607777; AllianceGenome:HGNC:19354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in cardiac muscle tissue development; negative regulation of transcription by RNA polymerase II; and skeletal muscle tissue development. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis (RPKM 19.2), endometrium (RPKM 17.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (16829398..16880349)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (16964243..17015192)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (16940209..16991160)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.
Title: Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.
Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder.
Title: Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder.
Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network.
Title: Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network.
Establishment of Novel Protein Interaction Assays between Sin3 and REST Using Surface Plasmon Resonance and Time-Resolved Fluorescence Energy Transfer.
Title: Establishment of Novel Protein Interaction Assays between Sin3 and REST Using Surface Plasmon Resonance and Time-Resolved Fluorescence Energy Transfer.
These studies identify Sin3B as a transcriptional corepressor associated with the DREAM complex in quiescence.
Title: The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence.
High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer.
Title: SIN3A and SIN3B differentially regulate breast cancer metastasis.
Low SIN3B expression is associated with Prostate Cancer Progression.
Title: Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence.
The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners.
Title: pH might play a role in regulating the function of paired amphipathic helices domains of human Sin3B by altering structure and thermodynamic stability.
A conserved Myc region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 is recruited to Myc-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc.
Title: Sin3b interacts with Myc and decreases Myc levels.
this study highlights an essential role for Sin3B in IFN-c induced COL1A2 repression in smooth muscle cells.
Title: Sin3B mediates collagen type I gene repression by interferon gamma in vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S930 (e-PCR)
- UniSTS:58389

A005U36 (e-PCR)
- UniSTS:7717

D19S199 (e-PCR), detects polymorphism
- UniSTS:147028

Sin3b (e-PCR), detects polymorphism
- UniSTS:472921

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sin3-type complex	NAS Non-traceable Author Statement more info	PubMed
located_in X chromosome	IEA Inferred from Electronic Annotation more info
located_in XY body	IEA Inferred from Electronic Annotation more info
located_in Y chromosome	IEA Inferred from Electronic Annotation more info
located_in autosome	IEA Inferred from Electronic Annotation more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: paired amphipathic helix protein Sin3b

Names: SIN3 homolog B, transcriptional regulator; SIN3 transcription regulator homolog B; histone deacetylase complex subunit Sin3b; transcriptional corepressor Sin3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001297595.2 → NP_001284524.1 paired amphipathic helix protein Sin3b isoform 2

See identical proteins and their annotated locations for NP_001284524.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AB014600, AY706204, HY055983

Consensus CDS

CCDS74308.1

UniProtKB/Swiss-Prot

O75182

Related

ENSP00000248054.4, ENST00000248054.10

Conserved Domains (3) summary

pfam02671
Location:60 → 104

PAH; Paired amphipathic helix repeat

pfam08295
Location:395 → 489

Sin3_corepress; Sin3 family co-repressor

pfam16879
Location:743 → 1043

Sin3a_C; C-terminal domain of Sin3a protein
NM_001297597.2 → NP_001284526.1 paired amphipathic helix protein Sin3b isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB014600, AK295618, AY706204, DC332740

Consensus CDS

CCDS77254.1

UniProtKB/TrEMBL

B7Z392, M0QYC5

Related

ENSP00000469740.1, ENST00000595541.1

Conserved Domains (2) summary

pfam08295
Location:12 → 79

Sin3_corepress; Sin3 family co-repressor

pfam16879
Location:333 → 633

Sin3a_C; C-terminal domain of Sin3a protein
NM_015260.4 → NP_056075.1 paired amphipathic helix protein Sin3b isoform 1

See identical proteins and their annotated locations for NP_056075.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AY706204, HY055983

Consensus CDS

CCDS32946.1

UniProtKB/Swiss-Prot

O75182, Q2NL91, Q68GC2, Q6P4B8, Q8TB34, Q9BSC8

Related

ENSP00000369131.1, ENST00000379803.5

Conserved Domains (3) summary

pfam02671
Location:60 → 104

PAH; Paired amphipathic helix repeat

pfam08295
Location:395 → 521

Sin3_corepress; Sin3 family co-repressor

pfam16879
Location:775 → 1075

Sin3a_C; C-terminal domain of Sin3a protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

16829398..16880349

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006722704.2 → XP_006722767.1 paired amphipathic helix protein Sin3b isoform X1

UniProtKB/TrEMBL

B7Z392

Conserved Domains (1) summary

pfam16879
Location:258 → 558

Sin3a_C; C-terminal domain of Sin3a protein