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    ZDHHC1 zinc finger DHHC-type containing 1 [ Homo sapiens (human) ]

    Gene ID: 29800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZDHHC1provided by HGNC
    Official Full Name
    zinc finger DHHC-type containing 1provided by HGNC
    Primary source
    HGNC:HGNC:17916
    See related
    Ensembl:ENSG00000159714 AllianceGenome:HGNC:17916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC-1; ZNF377; C16orf1; HSU90653
    Summary
    Enables palmitoyltransferase activity. Involved in antiviral innate immune response; positive regulation of defense response to virus by host; and protein palmitoylation. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 6.2), testis (RPKM 6.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZDHHC1 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67394152..67416477, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73188923..73211253, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67428055..67450380, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7602 Neighboring gene leucine rich repeat containing 36 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene tubulin polymerization promoting protein family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67439721-67440606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67440607-67441493 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67441494-67442379 Neighboring gene uncharacterized LOC124903702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67450269-67450926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67454837-67455408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67458128-67458722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67461918-67462452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67462453-67462987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67469389-67469890 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67477413-67478036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67478661-67479284 Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67481159-67481658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67485489-67486172 Neighboring gene Sharpr-MPRA regulatory region 10086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67495532-67496032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67499338-67499838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67499839-67500339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10966

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis. Le X, et al. Theranostics, 2020. PMID 32863941, Free PMC Article
    2. The DHHC domain: a new highly conserved cysteine-rich motif. Putilina T, et al. Mol Cell Biochem, 1999 May. PMID 10395086
    3. Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation. Tang J, et al. Oncogene, 2021 Sep. PMID 34282274, Free PMC Article
    4. ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation. Zhang Q, et al. Cancer Gene Ther, 2024 Sep. PMID 39069526, Free PMC Article
    5. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Zhou Q, et al. Cell Host Microbe, 2014 Oct 8. PMID 25299331

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation.
      Title: ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation.
    2. Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation.
      Title: Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation.
    3. DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis.
      Title: DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis.
    4. In an expression screen for proteins that can activate the IFNB1 promoter, authors identified the ER-associated protein ZDHHC1 as a positive regulator of virus-triggered, MITA/STING-dependent immune signaling.
      Title: The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.
    5. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
      Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    6. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide searching of rare genetic variants in WTCCC data.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC1
    Names
    DHHC domain-containing cysteine-rich protein 1
    probable palmitoyltransferase ZDHHC1
    zinc finger DHHC domain-containing protein 1
    zinc finger protein 377
    zinc finger, DHHC domain containing 1
    NP_001310556.1
    NP_037436.1
    XP_006721248.1
    XP_011521362.1
    XP_024306013.1
    XP_024306014.1
    XP_024306015.1
    XP_054236159.1
    XP_054236160.1
    XP_054236161.1
    XP_054236162.1
    XP_054236163.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323627.2 → NP_001310556.1  palmitoyltransferase ZDHHC1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009061, BM724650, BX111231, HY054038, U90653
      Consensus CDS
      CCDS92175.1
      UniProtKB/TrEMBL
      I3L202
      Related
      ENSP00000459264.2, ENST00000565726.3
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_013304.3 → NP_037436.1  palmitoyltransferase ZDHHC1 isoform 1

      See identical proteins and their annotated locations for NP_037436.1

      Status: VALIDATED

      Source sequence(s)
      AC009061, BC021908, CA432496, U90653
      Consensus CDS
      CCDS10836.1
      UniProtKB/Swiss-Prot
      O15461, Q8WTX9
      Related
      ENSP00000340299.2, ENST00000348579.6
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67394152..67416477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450247.2 → XP_024306015.1  palmitoyltransferase ZDHHC1 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_024450246.2 → XP_024306014.1  palmitoyltransferase ZDHHC1 isoform X3

      Conserved Domains (2) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase
      pfam03546
      Location:323 → 469
      Treacle; Treacher Collins syndrome protein Treacle

    3. XM_006721185.3 → XP_006721248.1  palmitoyltransferase ZDHHC1 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    4. XM_024450245.2 → XP_024306013.1  palmitoyltransferase ZDHHC1 isoform X1

      UniProtKB/Swiss-Prot
      O15461, Q8WTX9
      Conserved Domains (1) summary
      pfam01529
      Location:129 → 284
      zf-DHHC; DHHC palmitoyltransferase

    5. XM_011523060.2 → XP_011521362.1  palmitoyltransferase ZDHHC1 isoform X5

      Conserved Domains (1) summary
      pfam01529
      Location:44 → 199
      zf-DHHC; DHHC palmitoyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73188923..73211253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380187.1 → XP_054236162.1  palmitoyltransferase ZDHHC1 isoform X4

    2. XM_054380186.1 → XP_054236161.1  palmitoyltransferase ZDHHC1 isoform X3

    3. XM_054380185.1 → XP_054236160.1  palmitoyltransferase ZDHHC1 isoform X2

    4. XM_054380184.1 → XP_054236159.1  palmitoyltransferase ZDHHC1 isoform X1

      UniProtKB/Swiss-Prot
      O15461, Q8WTX9

    5. XM_054380188.1 → XP_054236163.1  palmitoyltransferase ZDHHC1 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WTX9.1 GenPept UniProtKB/Swiss-Prot:Q8WTX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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