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    Nxf3 nuclear RNA export factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 245610, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nxf3provided by MGI
    Official Full Name
    nuclear RNA export factor 3provided by MGI
    Primary source
    MGI:MGI:2685230
    See related
    Ensembl:ENSMUSG00000057000 AllianceGenome:MGI:2685230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm384
    Summary
    Enables mRNA binding activity. Acts upstream of or within poly(A)+ mRNA export from nucleus. Located in cytoplasm. Is expressed in testis. Orthologous to human NXF3 (nuclear RNA export factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 20.5) and genital fat pad adult (RPKM 12.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nxf3 in Genome Data Viewer
    Location:
    X F1; X 57.38 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134972272..135040382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136071523..136139579, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54084 Neighboring gene brain expressed X-linked 2 Neighboring gene RIKEN cDNA 5730412P04 gene Neighboring gene brain expressed X-linked 4 Neighboring gene transcription elongation factor A (SII)-like 8 Neighboring gene microRNA 6383

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within poly(A)+ mRNA export from nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear RNA export factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear RNA export factor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024141.4NP_001019312.1  nuclear RNA export factor 3

      See identical proteins and their annotated locations for NP_001019312.1

      Status: VALIDATED

      Source sequence(s)
      AL671914
      Consensus CDS
      CCDS41132.1
      UniProtKB/TrEMBL
      Q4ZGD9
      Related
      ENSMUSP00000079730.7, ENSMUST00000080929.13
      Conserved Domains (4) summary
      smart00804
      Location:485547
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:192230
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:99178
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:314470
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      134972272..135040382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161963.1XP_036017856.1  nuclear RNA export factor 3 isoform X3

      Conserved Domains (4) summary
      smart00804
      Location:486548
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:193231
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:86168
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:315471
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    2. XM_030251344.1XP_030107204.1  nuclear RNA export factor 3 isoform X1

      Conserved Domains (4) summary
      smart00804
      Location:499561
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:206244
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:99181
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:328484
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    3. XM_006528531.3XP_006528594.2  nuclear RNA export factor 3 isoform X2

      See identical proteins and their annotated locations for XP_006528594.2

      Conserved Domains (4) summary
      smart00804
      Location:493555
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:200238
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:93175
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:322478
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    4. XM_011247739.2XP_011246041.1  nuclear RNA export factor 3 isoform X2

      See identical proteins and their annotated locations for XP_011246041.1

      Conserved Domains (4) summary
      smart00804
      Location:493555
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:200238
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:93175
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:322478
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    5. XM_011247740.2XP_011246042.1  nuclear RNA export factor 3 isoform X3

      See identical proteins and their annotated locations for XP_011246042.1

      Conserved Domains (4) summary
      smart00804
      Location:486548
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:193231
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:86168
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:315471
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    6. XM_006528534.3XP_006528597.2  nuclear RNA export factor 3 isoform X3

      See identical proteins and their annotated locations for XP_006528597.2

      Conserved Domains (4) summary
      smart00804
      Location:486548
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:193231
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:86168
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:315471
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    7. XM_006528532.3XP_006528595.2  nuclear RNA export factor 3 isoform X3

      See identical proteins and their annotated locations for XP_006528595.2

      Conserved Domains (4) summary
      smart00804
      Location:486548
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:193231
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:86168
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:315471
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    8. XM_006528536.5XP_006528599.1  nuclear RNA export factor 3 isoform X4

      Conserved Domains (1) summary
      pfam09162
      Location:99181
      Tap-RNA_bind; Tap, RNA-binding