Gnb2 guanine nucleotide binding protein (G protein), beta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gnb2provided by MGI
Official Full Name: guanine nucleotide binding protein (G protein), beta 2provided by MGI
Primary source: MGI:MGI:95784
See related: Ensembl:ENSMUSG00000029713 AllianceGenome:MGI:95784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gnb-2; Hg2c1
Summary: Predicted to enable several functions, including GTPase activity; GTPase binding activity; and calcium channel regulator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of potassium ion transmembrane transport. Located in myelin sheath. Is active in synapse. Is expressed in several structures, including brain; eye; liver; oocyte; and pancreas epithelium. Orthologous to human GNB2 (G protein subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 211.7), adrenal adult (RPKM 206.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.54 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137526389..137533085, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137528127..137533449, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that G protein beta2 (Gbeta2) is required for starvation-induced NF-kappaB activation and constitutive NF-kappaB activity.
Title: Serum starvation activates NF-κB through G protein β2 subunit-mediated signal.
G protein subunits beta1 and beta2 have different roles in neutrophil function, as revealed by gene expression silencing in primary mouse neutrophils
Title: Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gnb2 (e-PCR), detects polymorphism
- UniSTS:496681

Gnb2 (e-PCR), detects polymorphism
- UniSTS:525225

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Names: g protein subunit beta-2; guanine nucleotide binding protein, beta 2; guanine nucleotide-binding protein, beta-2 subunit; heterotrimeric guanine nucleotide-binding protein 2c1; transducin beta chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010312.5 → NP_034442.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

See identical proteins and their annotated locations for NP_034442.1

Status: VALIDATED

Source sequence(s)

AI892088, AK146941, BF458455

Consensus CDS

CCDS19769.1

UniProtKB/Swiss-Prot

P62880

UniProtKB/TrEMBL

E9QKR0, Q3U9V4

Related

ENSMUSP00000031726.9, ENSMUST00000031726.15

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137526389..137533085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504553.5 → XP_006504616.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

See identical proteins and their annotated locations for XP_006504616.1

UniProtKB/Swiss-Prot

P62880

UniProtKB/TrEMBL

E9QKR0, Q3U9V4

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]