U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cckar cholecystokinin A receptor [ Mus musculus (house mouse) ]

    Gene ID: 12425, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cckarprovided by MGI
    Official Full Name
    cholecystokinin A receptorprovided by MGI
    Primary source
    MGI:MGI:99478
    See related
    Ensembl:ENSMUSG00000029193 AllianceGenome:MGI:99478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cholecystokinin receptor activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Predicted to be located in several cellular components, including endosome; nucleoplasm; and terminal bouton. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 14.7), kidney adult (RPKM 12.1) and 4 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cckar in Genome Data Viewer
    Location:
    5 C1; 5 29.52 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (53855827..53865046, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (53698485..53707704, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13086 Neighboring gene STARR-seq mESC enhancer starr_13089 Neighboring gene predicted gene, 40304 Neighboring gene STARR-seq mESC enhancer starr_13090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:53980216-53980325 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region Neighboring gene STARR-seq mESC enhancer starr_13092 Neighboring gene STARR-seq mESC enhancer starr_13095 Neighboring gene TBC1 domain family, member 19 Neighboring gene STARR-seq mESC enhancer starr_13097 Neighboring gene predicted gene, 40305

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasis. Zhu G, et al. Physiol Behav, 2012 Jan 18. PMID 21871472, Free PMC Article
    2. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. Kopin AS, et al. J Clin Invest, 1999 Feb. PMID 9927499, Free PMC Article
    3. Cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach of mice. Konno K, et al. Histochem Cell Biol, 2015 Mar. PMID 25249350
    4. Cholecystokinin: an excitatory modulator of mitral/tufted cells in the mouse olfactory bulb. Ma J, et al. PLoS One, 2013. PMID 23691163, Free PMC Article
    5. Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice. Irwin N, et al. Diabetologia, 2013 Jun. PMID 23462797

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway.
      Title: Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway.
    2. The studies establish chronic pancreatitis as an IL-33-dependent inflammation resulting from synergistic interactions between the NOD1 and CCKR signaling pathways.
      Title: Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis.
    3. There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
      Title: Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
    4. mice lacking CCK receptors exhibited a functional shift from the gastrin-CCK pathways to the neuronal pathway in control of the ECL cells and eventually the acid secretion
      Title: Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors.
    5. cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach
      Title: Cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach of mice.
    6. The lithogenic diet was associated with significantly lower CAV3 in the liver and lower CAV3 and CCKAR in the gallbladder compared with the control mice.
      Title: Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice.
    7. CCK-8S increases [Ca(2+)]i in gastric antral interstitial cells of Cajal via the CCK(1) receptor
      Title: Mechanisms of cholecystokinin-induced calcium mobilization in gastric antral interstitial cells of Cajal.
    8. CCK1 receptor activation does not have a greater effect combination with upregulated leptin signalling in high-fat-fed mice
      Title: Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice.
    9. Suggest role for ependymal CCK-1 receptors in infant satiety-controlling mechanisms.
      Title: Infant satiety depends on transient expression of cholecystokinin-1 receptors on ependymal cells lining the third ventricle in mice.
    10. CCK-1 and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 receptors may facilitate CCK-2 receptor signaling.
      Title: Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholecystokinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholecystokinin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholecystokinin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholecystokinin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reduction of food intake in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cholecystokinin receptor type A
    Names
    CCK-A receptor
    CCK-AR
    CCK1-R
    cholecystokinin-1 receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347354.1 → NP_001334283.1  cholecystokinin receptor type A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC084054, AC122196
      Consensus CDS
      CCDS84881.1
      UniProtKB/TrEMBL
      Q3TPL0
      Related
      ENSMUSP00000144103.2, ENSMUST00000200691.4

    2. NM_009827.2 → NP_033957.1  cholecystokinin receptor type A isoform 1

      See identical proteins and their annotated locations for NP_033957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK004730, AK147052
      Consensus CDS
      CCDS19293.1
      UniProtKB/Swiss-Prot
      O08786, Q8VCC7, Q9DBV6
      Related
      ENSMUSP00000031093.4, ENSMUST00000031093.5
      Conserved Domains (3) summary
      pfam00001
      Location:58 → 378
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam09193
      Location:1 → 47
      CholecysA-Rec_N; Cholecystokinin A receptor, N-terminal
      cl21561
      Location:48 → 196
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      53855827..53865046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08786.1 GenPept UniProtKB/Swiss-Prot:O08786

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous