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    Mov10 Mov10 RISC complex RNA helicase [ Mus musculus (house mouse) ]

    Gene ID: 17454, updated on 3-Dec-2024

    Summary

    Official Symbol
    Mov10provided by MGI
    Official Full Name
    Mov10 RISC complex RNA helicaseprovided by MGI
    Primary source
    MGI:MGI:97054
    See related
    Ensembl:ENSMUSG00000002227 AllianceGenome:MGI:97054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mov-10
    Summary
    Predicted to enable 5'-3' RNA helicase activity and RNA binding activity. Involved in regulation of neuron projection arborization and retrotransposon silencing. Located in cytosol and nucleus. Is expressed in brain; gut; sensory organ; testis; and turbinate bone primordium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human MOV10 (Mov10 RNA helicase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 17.0), small intestine adult (RPKM 14.9) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mov10 in Genome Data Viewer
    Location:
    3 F2.2; 3 45.87 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104702144..104725935, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104794828..104818619, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene protein phosphatase 1J Neighboring gene ras homolog family member C Neighboring gene STARR-seq mESC enhancer starr_08622 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104667925-104668034 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene ribosomal protein S27 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 5'-3' RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in 3'-UTR-mediated mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA-mediated gene silencing by mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transposable element silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transposable element silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transposable element silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transposable element silencing by mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative helicase MOV-10
    Names
    moloney leukemia virus 10 protein
    NP_001156912.2
    NP_001156913.1
    NP_001397354.1
    NP_001397355.1
    NP_001397356.1
    NP_001397357.1
    NP_032645.2
    XP_006501163.1
    XP_006501164.1
    XP_030108315.1
    XP_036018811.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163440.2NP_001156912.2  putative helicase MOV-10 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC171110
      Consensus CDS
      CCDS51033.1
      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Related
      ENSMUSP00000126897.2, ENSMUST00000166979.8
    2. NM_001163441.2NP_001156913.1  putative helicase MOV-10 isoform b

      See identical proteins and their annotated locations for NP_001156913.1

      Status: VALIDATED

      Source sequence(s)
      AC171110
      Consensus CDS
      CCDS38579.1
      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Related
      ENSMUSP00000128246.2, ENSMUST00000168015.8
      Conserved Domains (2) summary
      cd18808
      Location:735940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    3. NM_001410425.1NP_001397354.1  putative helicase MOV-10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171110
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
    4. NM_001410426.1NP_001397355.1  putative helicase MOV-10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171110
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
    5. NM_001410427.1NP_001397356.1  putative helicase MOV-10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171110
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
    6. NM_001410428.1NP_001397357.1  putative helicase MOV-10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171110
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
    7. NM_008619.3NP_032645.2  putative helicase MOV-10 isoform b

      See identical proteins and their annotated locations for NP_032645.2

      Status: VALIDATED

      Source sequence(s)
      AC171110
      Consensus CDS
      CCDS38579.1
      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Related
      ENSMUSP00000002297.6, ENSMUST00000002297.12
      Conserved Domains (2) summary
      cd18808
      Location:735940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104702144..104725935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252455.1XP_030108315.1  putative helicase MOV-10 isoform X2

      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Conserved Domains (2) summary
      cd18808
      Location:679884
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:443678
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    2. XM_036162918.1XP_036018811.1  putative helicase MOV-10 isoform X2

      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Conserved Domains (2) summary
      cd18808
      Location:679884
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:443678
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    3. XM_006501100.1XP_006501163.1  putative helicase MOV-10 isoform X1

      See identical proteins and their annotated locations for XP_006501163.1

      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Conserved Domains (2) summary
      cd18808
      Location:735940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    4. XM_006501101.4XP_006501164.1  putative helicase MOV-10 isoform X1

      See identical proteins and their annotated locations for XP_006501164.1

      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Conserved Domains (2) summary
      cd18808
      Location:735940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    RNA

    1. XR_375493.4 RNA Sequence

      Related
      ENSMUST00000106774.8