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    Ptk7 PTK7 protein tyrosine kinase 7 [ Mus musculus (house mouse) ]

    Gene ID: 71461, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptk7provided by MGI
    Official Full Name
    PTK7 protein tyrosine kinase 7provided by MGI
    Primary source
    MGI:MGI:1918711
    See related
    Ensembl:ENSMUSG00000023972 AllianceGenome:MGI:1918711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    chz; mPTK7/CCK4; 8430404F20Rik
    Summary
    Acts upstream of or within several processes, including cochlea morphogenesis; heart development; and morphogenesis of an epithelium. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; nervous system; paraxial mesenchyme; reproductive system; and sensory organ. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 30.4), ovary adult (RPKM 29.7) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptk7 in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46875377..46940975, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46564451..46630049, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cullin 9 Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675 Neighboring gene STARR-positive B cell enhancer ABC_E10957 Neighboring gene STARR-positive B cell enhancer ABC_E7536 Neighboring gene kinesin light chain 4 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene cullin 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cochlea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within convergent extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung-associated mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within wound healing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inactive tyrosine-protein kinase 7
    Names
    protein chuzhoi
    protein-tyrosine kinase 7
    pseudo tyrosine kinase receptor 7
    receptor tyrosine kinase-like protein
    tyrosine-protein kinase-like 7
    NP_780377.1
    XP_006524985.2
    XP_006524986.1
    XP_006524987.1
    XP_017173127.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175168.4NP_780377.1  inactive tyrosine-protein kinase 7 precursor

      See identical proteins and their annotated locations for NP_780377.1

      Status: VALIDATED

      Source sequence(s)
      AK053044, BC076578
      Consensus CDS
      CCDS37637.1
      UniProtKB/Swiss-Prot
      Q3V422, Q6W8S9, Q8BKG3, Q8CHK5, Q8K178
      Related
      ENSMUSP00000043703.9, ENSMUST00000044442.10
      Conserved Domains (8) summary
      cd05046
      Location:7821055
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd05760
      Location:138214
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00219
      Location:7931053
      TyrKc; Tyrosine kinase, catalytic domain
      smart00408
      Location:597661
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:3098
      IG; Immunoglobulin
      smart00410
      Location:590673
      IG_like; Immunoglobulin like
      pfam07679
      Location:404490
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:406490
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46875377..46940975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524924.2XP_006524987.1  inactive tyrosine-protein kinase 7 isoform X3

      Conserved Domains (6) summary
      cd05046
      Location:7681041
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd05760
      Location:124200
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:314376
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:587647
      Ig; Immunoglobulin domain
      pfam13927
      Location:205280
      Ig_3; Immunoglobulin domain
      cl11960
      Location:390476
      Ig; Immunoglobulin domain
    2. XM_017317638.1XP_017173127.1  inactive tyrosine-protein kinase 7 isoform X4

      Conserved Domains (5) summary
      cd05046
      Location:548821
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      smart00408
      Location:94156
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:367427
      Ig; Immunoglobulin domain
      pfam13927
      Location:260
      Ig_3; Immunoglobulin domain
      cl11960
      Location:170256
      Ig; Immunoglobulin domain
    3. XM_006524922.2XP_006524985.2  inactive tyrosine-protein kinase 7 isoform X1

      Conserved Domains (6) summary
      cd05046
      Location:7881061
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd05760
      Location:144220
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:334396
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:607667
      Ig; Immunoglobulin domain
      pfam13927
      Location:225300
      Ig_3; Immunoglobulin domain
      cl11960
      Location:410496
      Ig; Immunoglobulin domain
    4. XM_006524923.1XP_006524986.1  inactive tyrosine-protein kinase 7 isoform X2

      Conserved Domains (6) summary
      cd05046
      Location:8081081
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd05760
      Location:164240
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:354416
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:627687
      Ig; Immunoglobulin domain
      pfam13927
      Location:245320
      Ig_3; Immunoglobulin domain
      cl11960
      Location:430516
      Ig; Immunoglobulin domain