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    Efcab5 EF-hand calcium binding domain 5 [ Mus musculus (house mouse) ]

    Gene ID: 319634, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Efcab5provided by MGI
    Official Full Name
    EF-hand calcium binding domain 5provided by MGI
    Primary source
    MGI:MGI:2442440
    See related
    Ensembl:ENSMUSG00000050944 AllianceGenome:MGI:2442440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930563A03Rik
    Summary
    Predicted to enable calcium ion binding activity. Orthologous to human EFCAB5 (EF-hand calcium binding domain 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 14.7) and CNS E18 (RPKM 0.4) See more
    Orthologs
    human all
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    Genomic context

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    See Efcab5 in Genome Data Viewer
    Location:
    11 B5; 11 46.25 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76980236..77106926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77089904..77216227, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30048 Neighboring gene STARR-seq mESC enhancer starr_30049 Neighboring gene STARR-seq mESC enhancer starr_30050 Neighboring gene predicted gene, 22772 Neighboring gene nuclear speckle regulatory protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E592 Neighboring gene microRNA 423 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30052 Neighboring gene upstream transcription factor 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8428 Neighboring gene STARR-positive B cell enhancer ABC_E7022 Neighboring gene STARR-positive B cell enhancer ABC_E3978 Neighboring gene slingshot protein phosphatase 2 Neighboring gene predicted gene, 24989 Neighboring gene heat shock protein 1, alpha pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156377

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176965.4 → NP_795939.3  EF-hand calcium-binding domain-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      AL603842, AL663066, BX321897
      Consensus CDS
      CCDS36232.1
      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      76980236..77106926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246082.2 → XP_030101942.1  EF-hand calcium-binding domain-containing protein 5 isoform X4

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Conserved Domains (3) summary
      smart00065
      Location:1120 → 1212
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      PHA03169
      Location:519 → 820
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:406 → 600
      PRK12678; transcription termination factor Rho; Provisional

    2. XM_017314600.3 → XP_017170089.1  EF-hand calcium-binding domain-containing protein 5 isoform X9

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Conserved Domains (3) summary
      PHA03169
      Location:256 → 557
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:143 → 337
      PRK12678; transcription termination factor Rho; Provisional
      cl21515
      Location:857 → 949
      GAF; GAF domain

    3. XM_030246081.2 → XP_030101941.1  EF-hand calcium-binding domain-containing protein 5 isoform X4

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Conserved Domains (3) summary
      smart00065
      Location:1120 → 1212
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      PHA03169
      Location:519 → 820
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:406 → 600
      PRK12678; transcription termination factor Rho; Provisional

    4. XM_017314599.3 → XP_017170088.1  EF-hand calcium-binding domain-containing protein 5 isoform X8

      Conserved Domains (4) summary
      smart00065
      Location:1200 → 1292
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      PHA03169
      Location:599 → 900
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:543 → 748
      PRK12678; transcription termination factor Rho; Provisional
      pfam05186
      Location:219 → 271
      Dpy-30; Dpy-30 motif

    5. XM_030246084.2 → XP_030101944.1  EF-hand calcium-binding domain-containing protein 5 isoform X7

      Conserved Domains (4) summary
      smart00065
      Location:1240 → 1332
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      PHA03169
      Location:639 → 940
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:583 → 788
      PRK12678; transcription termination factor Rho; Provisional
      pfam05186
      Location:219 → 271
      Dpy-30; Dpy-30 motif

    6. XM_030246083.2 → XP_030101943.1  EF-hand calcium-binding domain-containing protein 5 isoform X5

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Conserved Domains (3) summary
      smart00065
      Location:1240 → 1332
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      PHA03169
      Location:639 → 940
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:526 → 720
      PRK12678; transcription termination factor Rho; Provisional

    7. XM_030246079.2 → XP_030101939.1  EF-hand calcium-binding domain-containing protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Conserved Domains (3) summary
      smart00065
      Location:1240 → 1332
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      PHA03169
      Location:639 → 940
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:526 → 720
      PRK12678; transcription termination factor Rho; Provisional

    8. XM_030246080.2 → XP_030101940.1  EF-hand calcium-binding domain-containing protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Conserved Domains (2) summary
      smart00065
      Location:1160 → 1252
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam03157
      Location:538 → 851
      Glutenin_hmw; High molecular weight glutenin subunit

    9. XM_017314594.2 → XP_017170083.1  EF-hand calcium-binding domain-containing protein 5 isoform X6

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Conserved Domains (3) summary
      smart00065
      Location:1102 → 1194
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      PHA03169
      Location:501 → 802
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:388 → 582
      PRK12678; transcription termination factor Rho; Provisional

    10. XM_017314595.3 → XP_017170084.1  EF-hand calcium-binding domain-containing protein 5 isoform X6

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Conserved Domains (3) summary
      smart00065
      Location:1102 → 1194
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      PHA03169
      Location:501 → 802
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:388 → 582
      PRK12678; transcription termination factor Rho; Provisional

    11. XM_017314601.2 → XP_017170090.1  EF-hand calcium-binding domain-containing protein 5 isoform X10

      UniProtKB/Swiss-Prot
      A0JP43, B0QZJ9, Q5NC53, Q8CBN1, Q8CDP1
      Related
      ENSMUSP00000104037.2, ENSMUST00000108400.8
      Conserved Domains (3) summary
      PHA03169
      Location:248 → 549
      PHA03169; hypothetical protein; Provisional
      PRK12678
      Location:135 → 329
      PRK12678; transcription termination factor Rho; Provisional
      cl21515
      Location:849 → 941
      GAF; GAF domain

    RNA

    1. XR_003949462.2 RNA Sequence

    2. XR_004936976.1 RNA Sequence

    3. XR_003949461.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JP43.2 GenPept UniProtKB/Swiss-Prot:A0JP43

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