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    Aoc2 amine oxidase copper containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 237940, updated on 27-Nov-2024

    Summary

    Official Symbol
    Aoc2provided by MGI
    Official Full Name
    amine oxidase copper containing 2provided by MGI
    Primary source
    MGI:MGI:2668431
    See related
    Ensembl:ENSMUSG00000078651 AllianceGenome:MGI:2668431
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAO
    Summary
    Predicted to enable copper ion binding activity and primary methylamine oxidase activity. Predicted to be involved in amine metabolic process. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human AOC2 (amine oxidase copper containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 7.8), mammary gland adult (RPKM 6.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Aoc2 in Genome Data Viewer
    Location:
    11 D; 11 64.7 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101214467..101220633)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101323640..101329807)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1, autophagy related Neighboring gene STARR-positive B cell enhancer ABC_E2370 Neighboring gene STARR-positive B cell enhancer ABC_E7066 Neighboring gene proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) Neighboring gene amine oxidase, copper containing 3 Neighboring gene glucose-6-phosphatase catalytic subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aliphatic amine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables primary methylamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables primary methylamine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables primary methylamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in amine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    amine oxidase [copper-containing] 2; retina-specific copper amine oxidase
    Names
    amine oxidase, copper containing 2 (retina-specific)
    retina-specific amine oxidase
    NP_849263.1
    XP_017170022.1
    XP_017170024.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178932.1NP_849263.1  amine oxidase [copper-containing] 2

      See identical proteins and their annotated locations for NP_849263.1

      Status: PROVISIONAL

      Source sequence(s)
      AF350445
      Consensus CDS
      CCDS25464.1
      UniProtKB/Swiss-Prot
      A2A4J0, Q80WP3, Q812C9
      UniProtKB/TrEMBL
      A2A4I9
      Related
      ENSMUSP00000040255.8, ENSMUST00000041095.14
      Conserved Domains (4) summary
      PRK11504
      Location:59719
      tynA; tyramine oxidase; Provisional
      pfam01179
      Location:314717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
      pfam02727
      Location:62148
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:165263
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101214467..101220633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314533.3XP_017170022.1  retina-specific copper amine oxidase isoform X1

      UniProtKB/TrEMBL
      A2A4I9
      Conserved Domains (3) summary
      pfam02727
      Location:62148
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:165262
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:308654
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
    2. XM_017314535.3XP_017170024.1  retina-specific copper amine oxidase isoform X2

      Conserved Domains (3) summary
      pfam02727
      Location:62148
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:165262
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:308552
      Cu_amine_oxid; Copper amine oxidase, enzyme domain

    RNA

    1. XR_004936952.1 RNA Sequence

    2. XR_004936953.1 RNA Sequence

    3. XR_004936954.1 RNA Sequence