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    Tmigd1 transmembrane and immunoglobulin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66601, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmigd1provided by MGI
    Official Full Name
    transmembrane and immunoglobulin domain containing 1provided by MGI
    Primary source
    MGI:MGI:1913851
    See related
    Ensembl:ENSMUSG00000020839 AllianceGenome:MGI:1913851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmigd; 2010002A20Rik
    Summary
    Enables cell-cell adhesion mediator activity and protein homodimerization activity. Involved in cell-cell adhesion. Acts upstream of or within several processes, including brush border assembly; cellular response to hydroperoxide; and intestinal epithelial cell maturation. Is active in cell surface. Orthologous to human TMIGD1 (transmembrane and immunoglobulin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 33.2) and kidney adult (RPKM 9.3) See more
    Orthologs
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    Genomic context

    See Tmigd1 in Genome Data Viewer
    Location:
    11 B5; 11 46.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76781946..76807413)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76891120..76916587)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30045 Neighboring gene carboxypeptidase D Neighboring gene predicted gene, 53688 Neighboring gene predicted gene, 40200 Neighboring gene STARR-seq mESC enhancer starr_30046 Neighboring gene STARR-positive B cell enhancer mm9_chr11:76759053-76759354 Neighboring gene STARR-seq mESC enhancer starr_30047 Neighboring gene bleomycin hydrolase Neighboring gene solute carrier family 6 member 4 gene promoter Neighboring gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Neighboring gene predicted gene 12343

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Gene trapped (1) 

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within brush border assembly PubMed 
    acts_upstream_of_or_within cell aggregation PubMed 
    acts_upstream_of_or_within cell migration PubMed 
    involved_in cell-cell adhesion PubMed 
    acts_upstream_of_or_within cell-cell junction organization PubMed 
    acts_upstream_of_or_within cellular response to hydroperoxide PubMed 
    acts_upstream_of_or_within intestinal epithelial cell maturation PubMed 
    acts_upstream_of_or_within intestinal epithelial cell migration PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within protein localization PubMed 
    involved_in regulation of cell migration  
    involved_in regulation of cell migration  
    involved_in regulation of cell population proliferation  
    involved_in regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of cyclin-dependent protein kinase activity PubMed 
    involved_in regulation of membrane permeability  
    involved_in regulation of membrane permeability  
    acts_upstream_of_or_within response to nutrient PubMed 
    Component Evidence Code Pubs
    located_in adherens junction PubMed 
    is_active_in cell surface PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrion  
    located_in mitochondrion  
    is_active_in neuron projection  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    transmembrane and immunoglobulin domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382246.1NP_001369175.1  transmembrane and immunoglobulin domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL603842
      UniProtKB/TrEMBL
      Q9D8H2
      Conserved Domains (2) summary
      smart00410
      Location:163244
      IG_like; Immunoglobulin like
      cd00096
      Location:171175
      Ig; Ig strand B [structural motif]
    2. NM_001382247.1NP_001369176.1  transmembrane and immunoglobulin domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL603842
      UniProtKB/TrEMBL
      Q9D8H2
      Conserved Domains (2) summary
      smart00410
      Location:163244
      IG_like; Immunoglobulin like
      cd00096
      Location:171175
      Ig; Ig strand B [structural motif]
    3. NM_025655.3NP_079931.1  transmembrane and immunoglobulin domain-containing protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_079931.1

      Status: VALIDATED

      Source sequence(s)
      AL603842
      Consensus CDS
      CCDS25072.1
      UniProtKB/Swiss-Prot
      Q8R202, Q9D7L8
      UniProtKB/TrEMBL
      Q9D8H2
      Related
      ENSMUSP00000099553.2, ENSMUST00000102495.8
      Conserved Domains (1) summary
      smart00409
      Location:130211
      IG; Immunoglobulin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      76781946..76807413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533950.3XP_006534013.1  transmembrane and immunoglobulin domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006534013.1

      UniProtKB/Swiss-Prot
      Q8R202, Q9D7L8
      UniProtKB/TrEMBL
      Q9D8H2
      Conserved Domains (1) summary
      smart00409
      Location:130211
      IG; Immunoglobulin
    2. XM_036156900.1XP_036012793.1  transmembrane and immunoglobulin domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      Q9D8H2
      Conserved Domains (2) summary
      smart00410
      Location:163244
      IG_like; Immunoglobulin like
      cd00096
      Location:171175
      Ig; Ig strand B [structural motif]
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