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    PUM2 pumilio RNA binding family member 2 [ Homo sapiens (human) ]

    Gene ID: 23369, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PUM2provided by HGNC
    Official Full Name
    pumilio RNA binding family member 2provided by HGNC
    Primary source
    HGNC:HGNC:14958
    See related
    Ensembl:ENSG00000055917 MIM:607205; AllianceGenome:HGNC:14958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PUMH2; PUML2
    Summary
    This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PUM2 in Genome Data Viewer
    Location:
    2p24.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (20248691..20352253, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (20282228..20385776, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (20448452..20552014, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr2:20440896-20441042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11204 Neighboring gene DRG1 pseudogene 1 Neighboring gene RNA, U7 small nuclear 113 pseudogene Neighboring gene RP9, pre-mRNA splicing factor pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15386 Neighboring gene H3K27ac hESC enhancers GRCh37_chr2:20550073-20550702 and GRCh37_chr2:20550703-20551334 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:20551335-20551964 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:20581046-20581877 Neighboring gene solute carrier family 7 member 15, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 86

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-κB pathway. Zhang X, et al. Biochem Biophys Res Commun, 2019 Apr 9. PMID 30824182
    2. Demonstration of protein cooperativity mediated by RNA structure using the human protein PUM2. Becker WR, et al. RNA, 2019 Jun. PMID 30914482, Free PMC Article
    3. Pseudouridine and N(6)-methyladenosine modifications weaken PUF protein/RNA interactions. Vaidyanathan PP, et al. RNA, 2017 May. PMID 28138061, Free PMC Article
    4. PUMILIO-2 is involved in the positive regulation of cellular proliferation in human adipose-derived stem cells. Shigunov P, et al. Stem Cells Dev, 2012 Jan 20. PMID 21649561, Free PMC Article
    5. Polymorphisms of the human PUMILIO2 gene and male sterility. Kusz K, et al. Mol Reprod Dev, 2007 Jun. PMID 17154300

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p.
      Title: RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p.
    2. Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.
      Title: Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.
    3. Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.
      Title: Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.
    4. CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging.
      Title: CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging.
    5. RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs.
      Title: RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs.
    6. Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.
      Title: Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.
    7. LncRNA TUG1 aggravates the progression of cervical cancer by binding PUM2.
      Title: LncRNA TUG1 aggravates the progression of cervical cancer by binding PUM2.
    8. The results suggest that PUM1-2 affects the expression of pluripotency genes as well as the efficiency of the cardiac differentiation process.
      Title: Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.
    9. circ_0075932 directly bound with the RNA-binding protein PUM2, which was reported to positively regulated AuroraA kinase, thus activating the NF-kappaB pathway. Moreover, either silencing PUM2, silencing AuroraA, or blockade of NF-kappaB activation, could abrogate the promoting effect of adipocyte-derived exosomal circ_0075932 on cell inflammation and apoptosis.
      Title: Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-κB pathway.
    10. A transcriptome-wide approach was used to determine the binding profiles and inter-dependencies of Argonaute2 (AGO2), Pumilio (PUM1 and PUM2) sites on mRNA 3' untranslated regions (3'UTRs).
      Title: Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with pumilio homolog 2 (PUM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36528, KIAA0235, MGC138251, MGC138253

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lncRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pumilio-response element binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hair follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of RIG-I signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of miRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sprouting of injured axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within post-transcriptional regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of intracellular mRNA localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of miRNA-mediated gene silencing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress granule assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pumilio homolog 2
    Names
    pumilio-2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282752.3 → NP_001269681.1  pumilio homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001269681.1

      Status: REVIEWED

      Source sequence(s)
      AC007041, AF315591, AK304198, BG717417
      UniProtKB/TrEMBL
      A0A0C4DG68
      Conserved Domains (1) summary
      cd07920
      Location:665 → 986
      Pumilio; Pumilio-family RNA binding domain

    2. NM_001282790.2 → NP_001269719.1  pumilio homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001269719.1

      Status: REVIEWED

      Source sequence(s)
      AC007041, AF315591, BC143550, BX094307
      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34
      Conserved Domains (1) summary
      cd07920
      Location:642 → 963
      Pumilio; Pumilio-family RNA binding domain

    3. NM_001282791.2 → NP_001269720.1  pumilio homolog 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC007041, AF272350, AF315591, BC143552, BX094307
      UniProtKB/TrEMBL
      A0A0C4DG68
      Related
      ENSP00000409905.1, ENST00000440577.5
      Conserved Domains (1) summary
      cd07920
      Location:586 → 907
      Pumilio; Pumilio-family RNA binding domain

    4. NM_001352917.3 → NP_001339846.1  pumilio homolog 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Consensus CDS
      CCDS92717.1
      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2
      Related
      ENSP00000516061.1, ENST00000704930.1
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1044
      Pumilio; Pumilio-family RNA binding domain

    5. NM_001352918.2 → NP_001339847.1  pumilio homolog 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Consensus CDS
      CCDS1698.1
      UniProtKB/TrEMBL
      A0A0C4DG68
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1042
      Pumilio; Pumilio-family RNA binding domain

    6. NM_001352919.3 → NP_001339848.1  pumilio homolog 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC007041
      Consensus CDS
      CCDS1698.1
      UniProtKB/TrEMBL
      A0A0C4DG68
      Related
      ENSP00000338173.5, ENST00000338086.9
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1042
      Pumilio; Pumilio-family RNA binding domain

    7. NM_001352920.3 → NP_001339849.1  pumilio homolog 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC007041
      UniProtKB/TrEMBL
      A0A0C4DG68
      Conserved Domains (1) summary
      cd07920
      Location:642 → 965
      Pumilio; Pumilio-family RNA binding domain

    8. NM_001352923.3 → NP_001339852.1  pumilio homolog 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC007041
      UniProtKB/TrEMBL
      A0A0C4DG68
      Conserved Domains (1) summary
      cd07920
      Location:642 → 965
      Pumilio; Pumilio-family RNA binding domain

    9. NM_001352925.3 → NP_001339854.1  pumilio homolog 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007041
      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34
      Conserved Domains (1) summary
      cd07920
      Location:642 → 963
      Pumilio; Pumilio-family RNA binding domain

    10. NM_001352926.2 → NP_001339855.1  pumilio homolog 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007041
      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34
      Conserved Domains (1) summary
      cd07920
      Location:642 → 963
      Pumilio; Pumilio-family RNA binding domain

    11. NM_001352927.3 → NP_001339856.1  pumilio homolog 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007041
      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34
      Conserved Domains (1) summary
      cd07920
      Location:642 → 963
      Pumilio; Pumilio-family RNA binding domain

    12. NM_001352928.3 → NP_001339857.1  pumilio homolog 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC007041
      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34
      Conserved Domains (1) summary
      cd07920
      Location:642 → 963
      Pumilio; Pumilio-family RNA binding domain

    13. NM_001352929.3 → NP_001339858.1  pumilio homolog 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC007041
      UniProtKB/TrEMBL
      A0A0C4DG68
      Conserved Domains (1) summary
      cd07920
      Location:586 → 907
      Pumilio; Pumilio-family RNA binding domain

    14. NM_001352930.3 → NP_001339859.1  pumilio homolog 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC007041
      UniProtKB/TrEMBL
      A0A0C4DG68
      Conserved Domains (1) summary
      cd07920
      Location:495 → 816
      Pumilio; Pumilio-family RNA binding domain

    15. NM_015317.5 → NP_056132.1  pumilio homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_056132.1

      Status: REVIEWED

      Source sequence(s)
      AC007041, AF315591, AK093847, BG717417
      Consensus CDS
      CCDS1698.1
      UniProtKB/TrEMBL
      A0A0C4DG68
      Related
      ENSP00000354370.4, ENST00000361078.7
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1042
      Pumilio; Pumilio-family RNA binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      20248691..20352253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443807.1 → XP_047299763.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    2. XM_047443803.1 → XP_047299759.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    3. XM_047443815.1 → XP_047299771.1  pumilio homolog 2 isoform X3

    4. XM_047443821.1 → XP_047299777.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    5. XM_006711974.3 → XP_006712037.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006712037.1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1044
      Pumilio; Pumilio-family RNA binding domain

    6. XM_047443814.1 → XP_047299770.1  pumilio homolog 2 isoform X3

    7. XM_005262609.2 → XP_005262666.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68
      Conserved Domains (1) summary
      cd07920
      Location:642 → 965
      Pumilio; Pumilio-family RNA binding domain

    8. XM_005262607.2 → XP_005262664.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_005262664.1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1044
      Pumilio; Pumilio-family RNA binding domain

    9. XM_047443812.1 → XP_047299768.1  pumilio homolog 2 isoform X3

    10. XM_047443825.1 → XP_047299781.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    11. XM_047443806.1 → XP_047299762.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    12. XM_047443804.1 → XP_047299760.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    13. XM_047443822.1 → XP_047299778.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    14. XM_047443819.1 → XP_047299775.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    15. XM_047443809.1 → XP_047299765.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    16. XM_047443802.1 → XP_047299758.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    17. XM_047443823.1 → XP_047299779.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    18. XM_047443817.1 → XP_047299773.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    19. XM_047443805.1 → XP_047299761.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    20. XM_011532721.3 → XP_011531023.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011531023.1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1044
      Pumilio; Pumilio-family RNA binding domain

    21. XM_047443813.1 → XP_047299769.1  pumilio homolog 2 isoform X3

    22. XM_047443824.1 → XP_047299780.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    23. XM_047443820.1 → XP_047299776.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    24. XM_047443808.1 → XP_047299764.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    25. XM_011532720.3 → XP_011531022.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011531022.1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1044
      Pumilio; Pumilio-family RNA binding domain

    26. XM_047443827.1 → XP_047299783.1  pumilio homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A0C4DG68

    27. XM_047443816.1 → XP_047299772.1  pumilio homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DG68

    28. XM_047443811.1 → XP_047299767.1  pumilio homolog 2 isoform X3

    29. XM_047443826.1 → XP_047299782.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    30. XM_047443818.1 → XP_047299774.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    31. XM_047443810.1 → XP_047299766.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    32. XM_011532719.2 → XP_011531021.1  pumilio homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011531021.1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1044
      Pumilio; Pumilio-family RNA binding domain

    33. XM_047443828.1 → XP_047299784.1  pumilio homolog 2 isoform X8

    34. XM_047443830.1 → XP_047299786.1  pumilio homolog 2 isoform X9

    35. XM_011532724.3 → XP_011531026.1  pumilio homolog 2 isoform X9

    36. XM_047443831.1 → XP_047299787.1  pumilio homolog 2 isoform X10

    37. XM_047443832.1 → XP_047299788.1  pumilio homolog 2 isoform X10

    38. XM_047443829.1 → XP_047299785.1  pumilio homolog 2 isoform X9

    39. XM_047443834.1 → XP_047299790.1  pumilio homolog 2 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      20282228..20385776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341172.1 → XP_054197147.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    2. XM_054341166.1 → XP_054197141.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    3. XM_054341180.1 → XP_054197155.1  pumilio homolog 2 isoform X3

    4. XM_054341185.1 → XP_054197160.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    5. XM_054341165.1 → XP_054197140.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    6. XM_054341179.1 → XP_054197154.1  pumilio homolog 2 isoform X3

    7. XM_054341186.1 → XP_054197161.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    8. XM_054341164.1 → XP_054197139.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    9. XM_054341177.1 → XP_054197152.1  pumilio homolog 2 isoform X3

    10. XM_054341192.1 → XP_054197167.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    11. XM_054341173.1 → XP_054197148.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    12. XM_054341170.1 → XP_054197145.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    13. XM_054341190.1 → XP_054197165.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    14. XM_054341187.1 → XP_054197162.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    15. XM_054341174.1 → XP_054197149.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    16. XM_054341167.1 → XP_054197142.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    17. XM_054341189.1 → XP_054197164.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    18. XM_054341182.1 → XP_054197157.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    19. XM_054341171.1 → XP_054197146.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    20. XM_054341163.1 → XP_054197138.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    21. XM_054341178.1 → XP_054197153.1  pumilio homolog 2 isoform X3

    22. XM_054341191.1 → XP_054197166.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    23. XM_054341184.1 → XP_054197159.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    24. XM_054341175.1 → XP_054197150.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    25. XM_054341168.1 → XP_054197143.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    26. XM_054341193.1 → XP_054197168.1  pumilio homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A0C4DG68

    27. XM_054341181.1 → XP_054197156.1  pumilio homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DG68

    28. XM_054341176.1 → XP_054197151.1  pumilio homolog 2 isoform X3

    29. XM_054341188.1 → XP_054197163.1  pumilio homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG68, B7ZL34

    30. XM_054341183.1 → XP_054197158.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG68

    31. XM_054341169.1 → XP_054197144.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG68

    32. XM_054341162.1 → XP_054197137.1  pumilio homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

    33. XM_054341194.1 → XP_054197169.1  pumilio homolog 2 isoform X8

    34. XM_054341196.1 → XP_054197171.1  pumilio homolog 2 isoform X9

    35. XM_054341197.1 → XP_054197172.1  pumilio homolog 2 isoform X9

    36. XM_054341200.1 → XP_054197175.1  pumilio homolog 2 isoform X10

    37. XM_054341201.1 → XP_054197176.1  pumilio homolog 2 isoform X10

    38. XM_054341199.1 → XP_054197174.1  pumilio homolog 2 isoform X10

    39. XM_054341195.1 → XP_054197170.1  pumilio homolog 2 isoform X9

    40. XM_054341198.1 → XP_054197173.1  pumilio homolog 2 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TB72.2 GenPept UniProtKB/Swiss-Prot:Q8TB72

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