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    CRIP3 cysteine rich protein 3 [ Homo sapiens (human) ]

    Gene ID: 401262, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CRIP3provided by HGNC
    Official Full Name
    cysteine rich protein 3provided by HGNC
    Primary source
    HGNC:HGNC:17751
    See related
    Ensembl:ENSG00000146215 AllianceGenome:HGNC:17751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TLP; CRP-3; TLP-A; h6LIMo
    Summary
    Predicted to enable metal ion binding activity. Predicted to act upstream of or within T cell proliferation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver (RPKM 2.8), heart (RPKM 2.6) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CRIP3 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43305472..43308826, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43134412..43137765, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43273210..43276564, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tau tubulin kinase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43239819-43240068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43245015-43245670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43245671-43246325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43254414-43255266 Neighboring gene Sharpr-MPRA regulatory region 10500 Neighboring gene uncharacterized LOC124901319 Neighboring gene solute carrier family 22 member 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43275224-43276081 Neighboring gene ribosomal protein L12 pseudogene 47 Neighboring gene ribosomal protein L34 pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis. Suzuki H, et al. Sci Rep, 2019 Mar 19. PMID 30890736, Free PMC Article
    2. The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern. Casrouge A, et al. Microbes Infect, 2004 Oct. PMID 15380775, Free PMC Article
    3. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis.
      Title: TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ZNF318

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich protein 3
    Names
    chromosome 6 LIM domain only protein
    thymus LIM protein TLP-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366068.1 → NP_001352997.1  cysteine-rich protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL583834
      Conserved Domains (2) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
      cd09477
      Location:80 → 133
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    2. NM_206922.3 → NP_996805.2  cysteine-rich protein 3 isoform 1

      See identical proteins and their annotated locations for NP_996805.2

      Status: VALIDATED

      Source sequence(s)
      AA813350, AI042209, AY555741, CN282994, CR976447
      Consensus CDS
      CCDS4894.2
      UniProtKB/Swiss-Prot
      A2A436, Q5T043, Q6Q6R4, Q6Q6R5, Q6Q6R6, Q6Q6R7
      Related
      ENSP00000361650.3, ENST00000372569.8
      Conserved Domains (2) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
      cd09477
      Location:124 → 177
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43305472..43308826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      43134412..43137765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q6R5.2 GenPept UniProtKB/Swiss-Prot:Q6Q6R5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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