RBMS2 RNA binding motif single stranded interacting protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBMS2provided by HGNC
Official Full Name: RNA binding motif single stranded interacting protein 2provided by HGNC
Primary source: HGNC:HGNC:9909
See related: Ensembl:ENSG00000076067 MIM:602387; AllianceGenome:HGNC:9909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SCR3
Summary: The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lung (RPKM 17.5), placenta (RPKM 15.2) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (56520405..56596193)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (56488069..56564187)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (56915604..56989977)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBMS2 acts as a tumor suppressor in breast cancer and positively regulated the expression of P21 by stabilizing its mRNA.
Title: RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

GDB:312714 (e-PCR)
- UniSTS:156429

GDB:434012 (e-PCR)
- UniSTS:157204

SHGC-58278 (e-PCR)
- UniSTS:25387

D5S2354 (e-PCR)
- UniSTS:473392

D8S2279 (e-PCR)
- UniSTS:473907

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

D2S1254 (e-PCR)
- UniSTS:24950

RH44533 (e-PCR)
- UniSTS:24197

SHGC-67307 (e-PCR)
- UniSTS:89991

T15358 (e-PCR)
- UniSTS:25247

STS-N33267 (e-PCR)
- UniSTS:43428

RH80724 (e-PCR)
- UniSTS:91304

RH102603 (e-PCR)
- UniSTS:96937

L18441 (e-PCR)
- UniSTS:71348

L17971 (e-PCR)
- UniSTS:43966

D12S1881 (e-PCR)
- UniSTS:6599

SHGC-132980 (e-PCR)
- UniSTS:170962

D15S1390 (e-PCR)
- UniSTS:474340

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA processing	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding motif, single-stranded-interacting protein 2

Names: suppressor of CDC2 with RNA-binding motif 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414459.1 → NP_001401388.1 RNA-binding motif, single-stranded-interacting protein 2 isoform 2

Status: REVIEWED

Source sequence(s)

AC090681, AC097104

UniProtKB/TrEMBL

F8W1T6
NM_001414460.1 → NP_001401389.1 RNA-binding motif, single-stranded-interacting protein 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC090681, AC097104
NM_001414461.1 → NP_001401390.1 RNA-binding motif, single-stranded-interacting protein 2 isoform 1

Status: REVIEWED

Source sequence(s)

AC090681, AC097104

UniProtKB/Swiss-Prot

Q15434

UniProtKB/TrEMBL

F8W1T6
NM_002898.4 → NP_002889.1 RNA-binding motif, single-stranded-interacting protein 2 isoform 1

See identical proteins and their annotated locations for NP_002889.1

Status: REVIEWED

Source sequence(s)

AC090681, AC097104, BC027863, CF890834, DC382164

Consensus CDS

CCDS8923.1

UniProtKB/Swiss-Prot

Q15434

UniProtKB/TrEMBL

F8W1T6

Related

ENSP00000262031.5, ENST00000262031.10

Conserved Domains (2) summary

cd12474
Location:135 → 220

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

cl17169
Location:49 → 134

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

56520405..56596193

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024449115.2 → XP_024304883.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X5

Conserved Domains (2) summary

cd12470
Location:19 → 104

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:105 → 190

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_005269059.6 → XP_005269116.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X3

Conserved Domains (2) summary

cd12470
Location:49 → 134

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:135 → 220

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_011538639.3 → XP_011536941.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X8

Conserved Domains (2) summary

cd12474
Location:135 → 220

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

cl17169
Location:49 → 134

RRM_SF; RNA recognition motif (RRM) superfamily
XM_005269060.6 → XP_005269117.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X7

Conserved Domains (2) summary

cd12470
Location:49 → 134

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:135 → 220

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_047429297.1 → XP_047285253.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X2
XM_006719541.5 → XP_006719604.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X1

Conserved Domains (2) summary

cd12470
Location:49 → 134

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:135 → 220

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_006719542.5 → XP_006719605.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X4

Conserved Domains (2) summary

cd12470
Location:49 → 134

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:135 → 220

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_005269066.5 → XP_005269123.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X10

Conserved Domains (1) summary

cl17169
Location:49 → 134

RRM_SF; RNA recognition motif (RRM) superfamily
XM_024449116.2 → XP_024304884.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X5

Conserved Domains (2) summary

cd12470
Location:19 → 104

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:105 → 190

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_047429298.1 → XP_047285254.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X6
XM_011538642.4 → XP_011536944.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X9

See identical proteins and their annotated locations for XP_011536944.1

Conserved Domains (1) summary

cd12474
Location:10 → 95

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

56488069..56564187

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372813.1 → XP_054228788.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X5
XM_054372811.1 → XP_054228786.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X3
XM_054372817.1 → XP_054228792.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X8
XM_054372816.1 → XP_054228791.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X7
XM_054372810.1 → XP_054228785.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X2
XM_054372809.1 → XP_054228784.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X1
XM_054372812.1 → XP_054228787.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X4
XM_054372819.1 → XP_054228794.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X10
XM_054372814.1 → XP_054228789.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X5
XM_054372815.1 → XP_054228790.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X6
XM_054372818.1 → XP_054228793.1 RNA-binding motif, single-stranded-interacting protein 2 isoform X9