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    TRIM36 tripartite motif containing 36 [ Homo sapiens (human) ]

    Gene ID: 55521, updated on 10-Dec-2024

    Summary

    Official Symbol
    TRIM36provided by HGNC
    Official Full Name
    tripartite motif containing 36provided by HGNC
    Primary source
    HGNC:HGNC:16280
    See related
    Ensembl:ENSG00000152503 MIM:609317; AllianceGenome:HGNC:16280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANPH; ANPH1; RNF98; HAPRIN; RBCC728
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues See more
    Orthologs
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    Genomic context

    See TRIM36 in Genome Data Viewer
    Location:
    5q22.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115124772..115180294, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (115637975..115693508, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114460469..114515991, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene potassium calcium-activated channel subfamily N member 2 Neighboring gene NANOG hESC enhancer GRCh37_chr5:113590875-113591386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:113613789-113614290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:113614291-113614790 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:113643487-113644315 Neighboring gene RN7SK pseudogene 89 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:113695880-113696796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16244 Neighboring gene NANOG hESC enhancer GRCh37_chr5:113724412-113724913 Neighboring gene uncharacterized LOC101927078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:113880373-113880872 Neighboring gene long intergenic non-protein coding RNA 1957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:114117551-114118374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:114118375-114119196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114364747-114365486 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114364005-114364746 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:114368052-114369251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22923 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:114404076-114405275 Neighboring gene Sharpr-MPRA regulatory region 9285 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114426221-114426720 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114426721-114427222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22927 Neighboring gene protein geranylgeranyltransferase type I subunit beta Neighboring gene ribosomal protein S2 pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of tripartite motif containing 36 (TRIM36) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-tubulin binding  
    enables protein binding PubMed 
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in acrosome reaction  
    involved_in mitotic cytokinesis PubMed 
    involved_in regulation of cell cycle  
    involved_in regulation of microtubule cytoskeleton organization PubMed 
    involved_in spindle organization  
    involved_in spindle organization PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle  
    located_in cytoplasm PubMed 
    located_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in plasma membrane  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM36
    Names
    RING finger protein 98
    RING-type E3 ubiquitin transferase TRIM36
    tripartite motif protein 36
    tripartite motif-containing protein 36
    zinc-binding protein Rbcc728
    NP_001017397.1
    NP_001017398.1
    NP_001287681.1
    NP_001287688.1
    NP_061170.2
    XP_016865110.1
    XP_016865111.1
    XP_016865112.1
    XP_047273316.1
    XP_047273317.1
    XP_047273318.1
    XP_054208879.1
    XP_054208880.1
    XP_054208881.1
    XP_054208882.1
    XP_054208883.1
    XP_054208884.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017397.2 → NP_001017397.1  E3 ubiquitin-protein ligase TRIM36 isoform 2

      See identical proteins and their annotated locations for NP_001017397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons, but has a much shorter and alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a much shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC046096
      Consensus CDS
      CCDS34211.1
      UniProtKB/Swiss-Prot
      Q9NQ86
      Related
      ENSP00000368938.2, ENST00000379618.6
    2. NM_001017398.2 → NP_001017398.1  E3 ubiquitin-protein ligase TRIM36 isoform 3

      See identical proteins and their annotated locations for NP_001017398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons, but has a much shorter and alternate 3' segment, as compared to variant 1. The resulting isoform (3) has a much shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC008494, AI142389, BF592910
      Consensus CDS
      CCDS34212.1
      UniProtKB/Swiss-Prot
      Q9NQ86
      Related
      ENSP00000368937.2, ENST00000379617.2
    3. NM_001300752.2 → NP_001287681.1  E3 ubiquitin-protein ligase TRIM36 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB196558, AC008494, AC094104, AJ272269
      Consensus CDS
      CCDS78047.1
      UniProtKB/TrEMBL
      E9PBG3, Q4R1Q4
      Related
      ENSP00000424259.1, ENST00000514154.1
      Conserved Domains (4) summary
      smart00060
      Location:276 → 336
      FN3; Fibronectin type 3 domain
      cd00021
      Location:56 → 94
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd12894
      Location:360 → 563
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      cl23765
      Location:101 → 225
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    4. NM_001300759.2 → NP_001287688.1  E3 ubiquitin-protein ligase TRIM36 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' terminal exon, compared to variant 1. The resulting isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC094104, AJ272269, AK296389, AK316422
      Consensus CDS
      CCDS75287.1
      UniProtKB/Swiss-Prot
      Q9NQ86
      Related
      ENSP00000423934.1, ENST00000513154.6
      Conserved Domains (5) summary
      smart00060
      Location:419 → 479
      FN3; Fibronectin type 3 domain
      cd00021
      Location:199 → 237
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:21 → 49
      zf-RING_UBOX; RING-type zinc-finger
      cd12894
      Location:503 → 706
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      cl23765
      Location:244 → 368
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    5. NM_018700.4 → NP_061170.2  E3 ubiquitin-protein ligase TRIM36 isoform 1

      See identical proteins and their annotated locations for NP_061170.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC008494, AC094104, AJ272269
      Consensus CDS
      CCDS4115.1
      UniProtKB/Swiss-Prot
      A1L3Z1, A6NDD0, B7Z3V4, B7ZAV7, E9PFI8, Q0P5Z9, Q9NQ86
      Related
      ENSP00000282369.3, ENST00000282369.7
      Conserved Domains (5) summary
      smart00060
      Location:431 → 491
      FN3; Fibronectin type 3 domain
      cd00021
      Location:211 → 249
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:33 → 61
      zf-RING_UBOX; RING-type zinc-finger
      cd12894
      Location:515 → 718
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      cl23765
      Location:256 → 380
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      115124772..115180294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009621.3 → XP_016865110.1  E3 ubiquitin-protein ligase TRIM36 isoform X1

    2. XM_017009622.3 → XP_016865111.1  E3 ubiquitin-protein ligase TRIM36 isoform X2

    3. XM_047417360.1 → XP_047273316.1  E3 ubiquitin-protein ligase TRIM36 isoform X3

    4. XM_047417361.1 → XP_047273317.1  E3 ubiquitin-protein ligase TRIM36 isoform X4

      UniProtKB/TrEMBL
      E9PBG3, Q4R1Q4
    5. XM_017009623.3 → XP_016865112.1  E3 ubiquitin-protein ligase TRIM36 isoform X5

    6. XM_047417362.1 → XP_047273318.1  E3 ubiquitin-protein ligase TRIM36 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      115637975..115693508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352904.1 → XP_054208879.1  E3 ubiquitin-protein ligase TRIM36 isoform X1

    2. XM_054352905.1 → XP_054208880.1  E3 ubiquitin-protein ligase TRIM36 isoform X2

    3. XM_054352906.1 → XP_054208881.1  E3 ubiquitin-protein ligase TRIM36 isoform X3

    4. XM_054352907.1 → XP_054208882.1  E3 ubiquitin-protein ligase TRIM36 isoform X4

      UniProtKB/TrEMBL
      Q4R1Q4
    5. XM_054352908.1 → XP_054208883.1  E3 ubiquitin-protein ligase TRIM36 isoform X5

    6. XM_054352909.1 → XP_054208884.1  E3 ubiquitin-protein ligase TRIM36 isoform X6

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