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    FKBP10 FKBP prolyl isomerase 10 [ Homo sapiens (human) ]

    Gene ID: 60681, updated on 10-Dec-2024

    Summary

    Official Symbol
    FKBP10provided by HGNC
    Official Full Name
    FKBP prolyl isomerase 10provided by HGNC
    Primary source
    HGNC:HGNC:18169
    See related
    Ensembl:ENSG00000141756 MIM:607063; AllianceGenome:HGNC:18169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OI6; BRKS; OI11; TLH1; BRKS1; FKBP65; PPIASE; hFKBP65
    Summary
    The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
    Expression
    Ubiquitous expression in placenta (RPKM 31.0), endometrium (RPKM 25.7) and 22 other tissues See more
    Orthologs
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    Genomic context

    See FKBP10 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41813004..41823213)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42669564..42679770)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39969256..39979465)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene junction plakoglobin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39927459-39927963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39927964-39928467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39932003-39932506 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:39942255-39942467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39947785-39948448 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39956106-39956612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39956613-39957119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12172 Neighboring gene prolyl 3-hydroxylase family member 4 (inactive) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39971057-39971558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39971559-39972058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39974907-39975818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39975819-39976730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39977650-39978248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39978249-39978845 Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12174 Neighboring gene kelch like family member 10 Neighboring gene kelch like family member 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40019607-40020116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8503

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ20683, FLJ22041, FLJ23833

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FK506 binding  
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity  
    enables calcium ion binding  
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in aorta morphogenesis  
    involved_in collagen fibril organization  
    involved_in extracellular matrix assembly  
    involved_in in utero embryonic development  
    involved_in protein folding  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in wound healing  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum lumen  
    located_in membrane  
    located_in mitochondrial intermembrane space  

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP10
    Names
    65 kDa FK506-binding protein
    65 kDa FKBP
    FK506 binding protein 10, 65 kDa
    FK506-binding protein 10
    FKBP-10
    FKBP-65
    PPIase FKBP10
    Telopeptide lysyl hydroxylase, bone-specific
    immunophilin FKBP65
    osteognesis imperfecta with congenital joint contractures
    rotamase
    NP_068758.3
    XP_011523401.1
    XP_011523402.1
    XP_047292471.1
    XP_054172841.1
    XP_054172842.1
    XP_054172843.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015860.1 RefSeqGene

      Range
      5001..15508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_12

    mRNA and Protein(s)

    1. NM_021939.4NP_068758.3  peptidyl-prolyl cis-trans isomerase FKBP10 precursor

      See identical proteins and their annotated locations for NP_068758.3

      Status: REVIEWED

      Source sequence(s)
      AF337909, AK092708, AL832985
      Consensus CDS
      CCDS11409.1
      UniProtKB/Swiss-Prot
      Q7Z3R4, Q96AY3, Q9H3N3, Q9H6J3, Q9H6N5, Q9UF89
      UniProtKB/TrEMBL
      Q658U4
      Related
      ENSP00000317232.4, ENST00000321562.9
      Conserved Domains (3) summary
      cd00051
      Location:506567
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:55147
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:504568
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41813004..41823213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525099.4XP_011523401.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X1

      UniProtKB/TrEMBL
      Q658U4
      Conserved Domains (3) summary
      cd00051
      Location:525586
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:55147
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:523587
      EF-hand_7; EF-hand domain pair
    2. XM_011525100.3XP_011523402.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X2

      Conserved Domains (3) summary
      cd00051
      Location:434495
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:76168
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:432496
      EF-hand_7; EF-hand domain pair
    3. XM_047436515.1XP_047292471.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X3

      UniProtKB/TrEMBL
      B4DJJ5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42669564..42679770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316866.1XP_054172841.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X1

      UniProtKB/TrEMBL
      Q658U4
    2. XM_054316867.1XP_054172842.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X2

    3. XM_054316868.1XP_054172843.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X3

      UniProtKB/TrEMBL
      B4DJJ5
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