GIHCG GIHCG inhibitor of miR-200b/200a/429 expression [Homo sapiens (human)] - Gene

Summary

Official Symbol: GIHCGprovided by HGNC
Official Full Name: GIHCG inhibitor of miR-200b/200a/429 expressionprovided by HGNC
Primary source: HGNC:HGNC:52649
See related: Ensembl:ENSG00000257698 AllianceGenome:HGNC:52649
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Biased expression in testis (RPKM 58.4), bone marrow (RPKM 20.9) and 12 other tissues See more
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Genomic context

Location:: 12q14.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (57931449..57936164, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (57899813..57904526, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (58325232..58329947, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GIHCG is highly expressed in ovarian cancer, which promotes tumor development by stimulating cell cycle progression and cell proliferation by regulating microRNA-429.
Title: LncRNA GIHCG promotes development of ovarian cancer by regulating microRNA-429.
Knockdown of GIHCG significantly represses proliferation and migration of renal cell carcinoma cells. Serum GIHCG level is positively correlated with GIHCG expression in RCC tissues.
Title: Long noncoding RNA GIHCG is a potential diagnostic and prognostic biomarker and therapeutic target for renal cell carcinoma.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

lncRNA gradually increased during hepatocarcinogenesis
lncRNA-GIHCG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.