PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRKAA1provided by HGNC
Official Full Name: protein kinase AMP-activated catalytic subunit alpha 1provided by HGNC
Primary source: HGNC:HGNC:9376
See related: Ensembl:ENSG00000132356 MIM:602739; AllianceGenome:HGNC:9376
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AMPK; AMPKa1; AMPK alpha 1
Summary: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in gall bladder (RPKM 18.4), thyroid (RPKM 16.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p13.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (40759389..40798374, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (41015789..41054877, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (40759491..40798476, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of Extreme Obesity.
Title: Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of Extreme Obesity.
Regulation of AMPK and GAPDH by Transglutaminase 2 Plays a Pivotal Role in Microvascular Leakage in Diabetic Retinas.
Title: Regulation of AMPK and GAPDH by Transglutaminase 2 Plays a Pivotal Role in Microvascular Leakage in Diabetic Retinas.
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy.
Title: MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy.
SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.
Title: SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.
SLC7A11-ROS/alphaKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression.
Title: SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression.
Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response.
Title: Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response.
Gene expression of protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), solute carrier family 2 member 1 (SLC2A1) and mechanistic target of rapamycin (MTOR) in metformin-treated type 2 diabetes patients with COVID-19: impact on inflammation markers.
Title: Gene expression of protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), solute carrier family 2 member 1 (SLC2A1) and mechanistic target of rapamycin (MTOR) in metformin-treated type 2 diabetes patients with COVID-19: impact on inflammation markers.
AMPKalpha1-mediated ZDHHC8 phosphorylation promotes the palmitoylation of SLC7A11 to facilitate ferroptosis resistance in glioblastoma.
Title: AMPKα1-mediated ZDHHC8 phosphorylation promotes the palmitoylation of SLC7A11 to facilitate ferroptosis resistance in glioblastoma.
NUSAP1 promotes pancreatic ductal adenocarcinoma progression by drives the epithelial-mesenchymal transition and reduces AMPK phosphorylation.
Title: NUSAP1 promotes pancreatic ductal adenocarcinoma progression by drives the epithelial-mesenchymal transition and reduces AMPK phosphorylation.
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA.
Title: Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA.

Submit: New GeneRIF Correction See all GeneRIFs (445)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway	PubMed
	tat	MiR-217 regulates HIV-1 Tat-induced activation of NF-kappaB and inactivation of AMPK in MAGI cells	PubMed
	tat	Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC)	PubMed
	tat	Knockdown of PRKAA1 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay	PubMed
Vif	vif	Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation	PubMed
Vpr	vpr	HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N23112 (e-PCR)
- UniSTS:79672

SGC34175 (e-PCR)
- UniSTS:65376

RH18516 (e-PCR)
- UniSTS:65377

RH71041 (e-PCR)
- UniSTS:69251

NM_006251 (e-PCR)
- UniSTS:497561

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables AMP-activated protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables AMP-activated protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed
enables tau-protein kinase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in CAMKK-AMPK signaling cascade	IC Inferred by Curator more info	PubMed
involved_in CAMKK-AMPK signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in CAMKK-AMPK signaling cascade	TAS Traceable Author Statement more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to prostaglandin E stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cold acclimation	IEA Inferred from Electronic Annotation more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid oxidation	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_positive_effect lipid droplet disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in motor behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glucosylceramide biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of hepatocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell mediated immune response to tumor cell	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adipose tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-lysine acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in protein localization to lipid droplet	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stress granule assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in response to UV	IEA Inferred from Electronic Annotation more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to caffeine	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to gamma radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	NAS Non-traceable Author Statement more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of nucleotide-activated protein kinase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of nucleotide-activated protein kinase complex	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 5'-AMP-activated protein kinase catalytic subunit alpha-1

Names: 5'-AMP-activated protein kinase, catalytic alpha-1 chain; ACACA kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK subunit alpha-1; AMPK, alpha, 1; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1

NP_001341957.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NP_001341958.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NP_001341963.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NP_001341964.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NP_001341965.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NP_001341966.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NP_006242.5

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NP_996790.3

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

XP_016865113.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

XP_054208885.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355028.2 → NP_001341957.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 3

Status: REVIEWED

Source sequence(s)

AC008810

Conserved Domains (3) summary

cd12199
Location:378 → 531

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

cd14403
Location:270 → 334

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cd14079
Location:17 → 253

STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
NM_001355029.2 → NP_001341958.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 4

Status: REVIEWED

Source sequence(s)

AC008810

Conserved Domains (3) summary

cd12199
Location:260 → 413

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

cd14403
Location:152 → 216

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cl21453
Location:1 → 135

PKc_like; Protein Kinases, catalytic domain
NM_001355034.2 → NP_001341963.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 5

Status: REVIEWED

Source sequence(s)

AC008810

UniProtKB/TrEMBL

Q96E92

Related

ENSP00000296800.4, ENST00000296800.4

Conserved Domains (1) summary

cl21453
Location:24 → 199

PKc_like; Protein Kinases, catalytic domain
NM_001355035.2 → NP_001341964.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform 6.

Source sequence(s)

AC008810

Conserved Domains (3) summary

cd12199
Location:146 → 299

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

cd14403
Location:38 → 102

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cl21453
Location:1 → 21

PKc_like; Protein Kinases, catalytic domain
NM_001355036.2 → NP_001341965.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform 6.

Source sequence(s)

AC008810

Conserved Domains (3) summary

cd12199
Location:146 → 299

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

cd14403
Location:38 → 102

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cl21453
Location:1 → 21

PKc_like; Protein Kinases, catalytic domain
NM_001355037.2 → NP_001341966.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform 6.

Source sequence(s)

AC008810

Conserved Domains (3) summary

cd12199
Location:146 → 299

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

cd14403
Location:38 → 102

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cl21453
Location:1 → 21

PKc_like; Protein Kinases, catalytic domain
NM_006251.6 → NP_006242.5 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1

See identical proteins and their annotated locations for NP_006242.5

Status: REVIEWED

Source sequence(s)

AC008810

Consensus CDS

CCDS3932.2

UniProtKB/Swiss-Prot

A8MTQ6, B2R7E1, O00286, Q13131, Q5D0E1, Q86VS1, Q9UNQ4

Related

ENSP00000380317.2, ENST00000397128.7

Conserved Domains (3) summary

cd12199
Location:404 → 557

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

cd14403
Location:296 → 360

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cd14079
Location:24 → 279

STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
NM_206907.4 → NP_996790.3 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2

See identical proteins and their annotated locations for NP_996790.3

Status: REVIEWED

Source sequence(s)

AC008810

Consensus CDS

CCDS3933.2

UniProtKB/Swiss-Prot

Q13131

Related

ENSP00000346148.3, ENST00000354209.7

Conserved Domains (3) summary

cd12199
Location:419 → 572

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

cd14403
Location:311 → 375

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cd14079
Location:24 → 294

STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase